Exogenous Ketone Supplementation to Improve Cardiovascular Disease Risk Factors in Females with Polycystic Ovary Syndrome

What this Trial Is About

Polycystic ovary syndrome (PCOS) affects many females of reproductive age and is linked to important heart health risk factors like insulin resistance, blood vessel problems, and high blood pressure. Because heart disease is a leading cause of death among females, this research aims to study how to improve cardiovascular health for females with PCOS by using a ketone supplement. The study is conducted by McGill University and compares responses in females with PCOS to those in healthy females of similar age and body size. Participants will attend two sessions on different days where they will drink either a beverage containing a ketone supplement or a placebo beverage. The ketone drink contains a specific ketone monoester given based on body weight mixed with water and vanilla stevia, while the placebo is a similar-tasting water-based drink. The study measures how these drinks affect blood sugar control, blood vessel function, blood pressure, and blood flow during exercise. During the study visits, participants will undergo a glucose tolerance test, blood pressure monitoring, and a blood vessel function test called flow-mediated dilation. Blood and other measurements will be collected over several hours after drinking the supplement or placebo. Researchers will also monitor hormones and nerve activity related to cardiovascular function. The total participation includes two study days and careful monitoring of heart and metabolic health responses to the supplements.

Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome