Study of the EXOPULSE Suit to Improve Walking in Adults with Multiple Sclerosis

What this Trial Is About

Researchers are evaluating the EXOPULSE Suit, a medical device designed to stimulate multiple muscle groups to help relax tense and spastic muscles, in people with Multiple Sclerosis MS. The study aims to confirm whether this device can improve walking ability compared to a sham version. This research is important for individuals with MS who experience reduced mobility and may not be able to use drug treatments like Fampridine due to side effects or other reasons. The EXOPULSE Suit is a wearable device with 50 electrodes that stimulate up to 43 major muscle groups. Participants will use the suit for one hour every other day at home. The study uses a randomized crossover design where participants first use the active suit for 4 weeks, then have a 4-week washout period, followed by 4 weeks using the sham suit, or vice versa. The sham suit provides stimulation only during the first minute, then turns off. During the study, participants will be assessed through various tests including walking scales, timed walk tests, and fatigue and pain questionnaires over 28-day periods. Researchers will monitor walking ability and muscle spasticity, among other outcomes. Participants must attend all medical visits and will be monitored throughout the study, which starts in March 2026 and continues until March 2027.

EXOPULSE Suit and Walking Ability of Patients With Multiple Sclerosis