Study of MyoPro Exoskeletal Device Combined with Motor Learning Therapy for Severe Arm Weakness After Chronic Stroke

What this Trial Is About

Researchers are studying the use of a wearable device called the MyoPro, combined with motor learning-based therapy, to help people who have had a stroke more than six months ago and have severe arm movement problems. This randomized controlled trial aims to compare the effects of using the MyoPro with therapy versus therapy alone. The study also looks at brain changes, biomarkers predicting better response, and cost-effectiveness of the combined treatment. Participants will be randomly assigned to one of two groups one receiving the MyoPro device paired with motor learning therapy, and the other receiving motor learning therapy alone. The therapy involves high-repetition training of specific arm and hand movements both in the clinic and at home. The program includes 18 in-clinic sessions over 9 weeks followed by 9 weeks of home exercises, with a 6-week follow-up period. The MyoPro device assists users by detecting weak muscle signals and helping move the affected arm, providing real-time feedback. During the study, participants will complete various assessments at multiple time points including motor function tests, muscle tone measurements, arm ability evaluations, sensory tests, and quality of life surveys. Brain imaging and stimulation tests will monitor brain changes. Participants will keep logs of home practice and device use. The main outcome measured is improvement in upper limb motor function, with additional tests evaluating arm performance, brain connectivity, and cost-effectiveness. The full study duration includes treatment and follow-up lasting about 24 weeks.

Exoskeleton Research: Myoelectric Orthosis for Rehab of Severe Chronic Arm Motor Deficits