Actively Recruiting
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer
Led by City of Hope Medical Center · Updated on 2025-12-01
400
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recent studies have highlighted the potential benefits of neoadjuvant chemotherapy (NAC) in colon cancer; however, its indication is generally limited to cases corresponding to pathological stage IIB or higher. Accurately identifying such high-risk cases before surgery remains challenging using conventional clinical diagnostics alone. Therefore, we hypothesized that integrating molecular biomarkers with preoperative clinical assessment could provide a more precise and sensitive evaluation of tumor aggressiveness. In this context, we focused on exosomal microRNAs, which are actively secreted from tumor cells and remain stable in circulation, and aimed to develop a machine learning-based biomarker panel. To achieve this, we initiated a multicenter study utilizing preoperative plasma samples to establish a reliable biomarker model for risk stratification and treatment decision-making in colon cancer.
CONDITIONS
Official Title
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed colon cancer (Stage I-IV, UICC TNM 8th edition)
- Underwent curative-intent resection (with or without perioperative therapy)
- Preoperative plasma (or serum) samples available
- Clinical and prognostic data available
You will not qualify if you...
- No written informed consent
- Missing preoperative blood samples
- Missing survival/recurrence data
- Duplicate cases
- Non-adenocarcinoma histology
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91016
Actively Recruiting
Research Team
A
Ajay Goel, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here