Actively Recruiting
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Led by City of Hope Medical Center · Updated on 2026-04-03
400
Participants Needed
5
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.
CONDITIONS
Official Title
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A histologically confirmed diagnosis of hepatocellular carcinoma
- A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
You will not qualify if you...
- Lack of or inability to provide informed consent
- Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
- Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
- Secondary liver cancer
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
2
Graduate School of Medical Sciences, Kyushu University
Fukuoka, Japan
Actively Recruiting
3
Graduate School of Medical Sciences, Kumamoto University
Kumamoto, Japan
Actively Recruiting
4
Hokkaido University Graduate School of Medicine
Sapporo, Japan
Actively Recruiting
5
Tokushima University
Tokushima, Japan
Actively Recruiting
Research Team
A
Ajay Goel, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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