Analyzing Plasma Exosomes to Understand and Treat Sjogrens Syndrome and Dry Eye Syndrome

What this Trial Is About

This research aims to understand the pathological mechanisms of Sjogrens Syndrome SJS and Dry Eye Syndrome DES by analyzing the proteins found in exosomes, small particles involved in cell communication. The study focuses on identifying potential diagnostic tools and treatment methods to improve care for people with these conditions. It builds on previous research evaluating herbal tea and acupuncture treatments for dry eye and mouth symptoms in SJS and DES patients. Participants will be divided into groups receiving acupuncture at specific points GB20 or GB20 plus BL2 twice weekly for 8 weeks, or Chinese herbal tea TBDESJS for 8 weeks. Healthy controls will not receive treatment. The study will use various tests and analyses including proteomics, exosome-miRNA, transcriptome, oral microbiota, Schirmers test, tear breakup time, and Traditional Chinese Medicine TCM assessments such as tongue and pulse diagnosis to evaluate treatment effects. During the study, participants will undergo assessments at baseline and after 8 weeks of treatment or observation. These include primary outcome measures like Schirmers test and the Ocular Surface Disease Index OSDI, along with secondary measures such as TCM pattern, cytokine markers, sleep quality indexes, and genetic testing. Researchers will monitor changes in these measures to explore immune regulation and treatment mechanisms, aiming for future clinical application to improve holistic health care for SJS and DES patients.

Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome