Actively Recruiting
EXpain Trial - Exercise an a Non-pharmacological Pain-relieving Treatment in People With Multiple Sclerosis
Led by University of Aarhus · Updated on 2026-01-15
116
Participants Needed
1
Research Sites
132 weeks
Total Duration
On this page
Sponsors
U
University of Aarhus
Lead Sponsor
A
Aalborg University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary goal of this study is to test whether 12 weeks of progressive resistance exercise is an effective non-pharmacological treatment for reducing pain in people with multiple sclerosis and chronic pain. The study will be a randomized controlled trial with multiple training sites. After baseline testing, participants will be randomly assigned to either a 12-week progressive resistance exercise intervention followed by a 12-week follow-up period or to a 24-week waitlist control group that receives usual care. It is hypothesized that people with multiple sclerosis and chronic pain who receive the intervention will experience greater reductions in pain (i.e., clinically relevant reductions) compared to the waitlist control group (primary hypothesis), and that this pain reduction will be preserved after a 12-week follow-up period (secondary hypothesis).
CONDITIONS
Official Title
EXpain Trial - Exercise an a Non-pharmacological Pain-relieving Treatment in People With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Average pain level greater than 3 on a 0-10 Numerical Rating Scale
- Age 18 years or older
- Valid diagnosis of multiple sclerosis (ICD-10 code: G35)
- Ability to transport yourself to testing and exercise sessions
You will not qualify if you...
- Pregnancy
- Diabetes
- Neurological or other health conditions that prevent study participation
- MS relapse within the past 2 months
- High cardiovascular risk as defined by American College of Sports Medicine guidelines
- Participation in structured exercise sessions two or more times per week within the past 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aarhus University
Aarhus, Denmark, Denmark, 8000
Actively Recruiting
Research Team
R
Rasmus C Jungersen, PhD-student
CONTACT
L
Lars G Hvid, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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