Actively Recruiting
Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg
Led by University of Rochester · Updated on 2025-08-13
500
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis. The proposed research will explore the development of sensitization to these food(s) in infants based on maternal consumption or avoidance during pregnancy and breastfeeding.
CONDITIONS
Official Title
Expecting Mother's Study of Consumption or Avoidance of Peanut and Egg
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to understand and provide informed consent
- English-speaking adults 18 years or older (Spanish speakers may be included if translation and support are available)
- Maternal consent provided for infants
- Pregnant women from confirmed pregnancy until 27 weeks gestation
- No chronic inflammatory conditions needing long-term immunosuppressive medications in first or second trimester
- Carrying a fetus with a first-degree relative having allergic disease (asthma, allergic rhinitis, atopic dermatitis, or food allergy)
- Intend to breastfeed their infant exclusively for more than 3 months
- Have eaten peanut and egg with no food allergy reactions
- Willing to be randomized to either consume or avoid peanut and egg
- Uncomplicated pregnancy (no gestational diabetes, preeclampsia, or hyperemesis gravidarum)
You will not qualify if you...
- Unable or unwilling to give written informed consent or comply with the study protocol
- Known kidney, liver, or heart failure in mother or infant
- Pregnant women with peanut or egg allergy
- Pregnant women who refuse to eat peanut and/or eggs
- Physician-diagnosed immunodeficiency in mother or infant
- Current diagnosed mental illness or drug/alcohol abuse interfering with study compliance
- Past or current medical problems posing risk to mother or infant or affecting study data quality, as determined by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
A
Allison W Leadley, MPH
CONTACT
L
Leanna Twohig, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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