Actively Recruiting
Exploration of Gender Differences in Liver Aging
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2024-10-08
18
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The liver is an important metabolic organ in the body. It participates in central metabolic activities to maintain systemic homeostasis. It is also one of the most vulnerable organs in the process of individual aging. During aging, the volume, blood flow, metabolic capacity and regenerative capacity of the liver decrease. Liver function changes with age can lead to age-related systemic susceptibility diseases. Therefore, understanding the changes of metabolism and immune function in the process of liver aging and studying the regulation mechanism of liver aging will provide an important reference for understanding the causes of increased susceptibility to liver-related diseases in the elderly population.On the other hand, gender factors also affect organ function, leading to differences in human aging and disease outcomes.At present, the omics research on liver aging is mainly based on tissue-level transcription, protein or metabolomics, and most of the conclusions are focused on hepatocytes. However, for other cell types and microenvironment interactions, people know little about the aging changes at the cellular levelBased on the current research status, this study aims to explore the gender differences in the process of liver aging, using emerging technologies such as the combination of single-cell multi-omics and spatial localization, to reveal the factors driving liver aging from a gender perspective, and to promote the development of accurate interventions for aging and aging-related diseases.
CONDITIONS
Official Title
Exploration of Gender Differences in Liver Aging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Liver function indicators are within the normal reference range.
- Liver imaging examination shows normal results.
You will not qualify if you...
- History of liver-related diseases.
- Important organ dysfunction or failure, or serious diseases such as myocardial infarction, malignant tumor, severe neurological or psychiatric conditions, severe infection, or coagulation dysfunction.
- Moderate malnutrition (BMI less than 17 kg/m2) or severe anemia (hemoglobin less than 60 g/L).
- Disagreement with the study protocol by the participant or their family.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, China, No.88 Jiefang Road
Actively Recruiting
Research Team
D
daren Liu, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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