Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal

What this Trial Is About

Researchers are conducting an observational study to understand why some adult patients with chronic obstructive pulmonary disease (COPD) experience failure when being weaned off invasive mechanical ventilation. The study focuses on adults who have been invasively ventilated for at least 48 hours and are ready for a spontaneous breathing test (SBT). Patients will be grouped based on whether they successfully withdraw from ventilation or not, to compare physiological changes during the breathing test. Participants will undergo a spontaneous breathing test using a low-level pressure support mode to assess readiness for ventilator withdrawal. Before the test, baseline demographic and physiological data, including vital signs and respiratory mechanics, will be collected. Researchers will monitor parameters such as maximal transdiaphragmatic pressure, twitch diaphragmatic pressure, and diaphragmatic electromyography to record respiratory function during the test. Throughout the study, data on breathing success or failure within 48 hours after extubation will be collected. Participants will be monitored for changes in respiratory mechanics and other vital signs during the SBT. The primary measurement is whether patients successfully wean off ventilation by day 2. The study may include healthy volunteers and will last until December 2025, with ongoing observation and data collection to better understand factors involved in ventilator withdrawal outcomes.

Exploration of Mechanisms for Weaning Failure