Actively Recruiting
Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA
Led by Fudan University · Updated on 2024-06-04
1100
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Following systemic therapy in metastatic colorectal cancer(mCRC),RAS (including KRAS, NRAS and HRAS gene) status may change from a mutant(MT) to a wild-type(WT),a phenomenon known as "NeoRAS WT"mCRC.NeoRAS WT can be detected by longitudinal circulating tumor DNA(ctDNA) analysis.Therefore, this prospective phase II Study was design to explore the detection rate of peripheral blood ctDNA testing for NeoRAS WT and its guiding value for subsequent treatment for mCRC.
CONDITIONS
Official Title
Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Metastatic colorectal cancer with tissue RAS mutation-type
- ECOG (Eastern Cooperative Oncology Group) performance score of 0-1
- Ability to provide informed consent
- Availability of surgical or punctured tissue specimens containing tumors
- Ability to provide 10ml of peripheral blood
You will not qualify if you...
- Pathology not confirmed by colonoscopy biopsy or biopsy of metastasis
- Patients with colorectal cancer stages I-III
- Patients with RAS wild-type metastatic colorectal cancer confirmed by histological genetic testing
- Lack of adequate organ functions, including severe abnormalities in blood, liver, or kidney function
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
Research Team
J
Junjie Peng, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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