Actively Recruiting
An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer
Led by Anhui Provincial Cancer Hospital · Updated on 2024-06-21
500
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the effect of statins combined with conventional chemotherapy and maintenance therapy on the prognosis of ovarian cancer patients, exploring its potential to improve survival rates and quality of life.
CONDITIONS
Official Title
An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 years and older
- Diagnosed with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer confirmed by pathology
- Require neoadjuvant chemotherapy followed by surgery or direct surgical chemotherapy
- Liver function with total bilirubin 641.5 times upper limit of normal (ULN) or direct bilirubin 641.0 times ULN
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) 642.5 times ULN; if liver metastases present, AST and ALT 645 times ULN
- Kidney function with serum creatinine 641.5 times ULN or creatinine clearance rate 6560 mL/min
- Able to understand and comply with trial procedures, treatments, tests, follow-ups, and questionnaires
You will not qualify if you...
- Using other investigational drugs or participating in other clinical drug trials
- Using medications that interact with statins
- Have active cirrhosis, uncontrolled diseases, chronic myopathy history, active hepatitis, or unexplained elevated serum aminotransferases
- Allergic to statins or similar drug components
- Unable to swallow oral medication or have gastrointestinal disorders affecting drug absorption or metabolism
- Require treatment for symptomatic or uncontrolled brain metastases or have clinical signs of spinal cord compression
- Have severe uncontrolled diseases such as active viral infections (HIV, hepatitis B or C), severe cardiovascular diseases, uncontrolled seizures, unstable spinal cord compression, superior vena cava syndrome, or psychiatric disorders affecting consent
- Have uncontrolled hypertension not managed by medication or immune deficiencies
- Medical history or conditions that may interfere with study adherence or safety
- History or current evidence of other malignancies
- Pregnant, breastfeeding, or planning pregnancy during the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Anhui Cancer Hospital
Hefei, Anhui, China, 230001
Actively Recruiting
Research Team
B
Bai-Rong Xia, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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