Actively Recruiting
Study of Recovery After Abdominal Surgery in Newborns Using Arginine and ADMA Levels
Led by Liverpool Women's NHS Foundation Trust · Updated on 2025-09-29
30
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
L
Liverpool Women's NHS Foundation Trust
Lead Sponsor
A
Alder Hey Children's NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the levels of two naturally occurring amino acids, Arginine and Asymmetric Dimethylarginine ADMA, in newborns undergoing abdominal surgery within the first five days of life due to congenital abdominal malformations. The study aims to understand how the relationship between these amino acids may predict recovery and complications after surgery, based on previous findings in adult patients. This observational, physiological study is conducted across two hospitals within the Liverpool Neonatal Partnership.
CONDITIONS
Brief Title
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants born after 35 weeks gestation
- Infants with a condition requiring major gastrointestinal surgery
- Surgery must occur within the first 5 days (120 hours) after birth
- Parent(s)/guardian(s) must understand written and spoken English sufficiently to provide informed consent
- Parent(s)/guardian(s) must be willing and able to provide informed consent
You will not qualify if you...
- Infants unlikely to survive due to poor immediate postoperative condition
- Infants with a known or suspected inborn error of metabolism or serious liver dysfunction
- Parent(s)/guardian(s) unable to provide informed consent
- Infants from whom the minimum required residual serum samples cannot be obtained from routine blood testing
Research Team
C
Colin Morgan
J
Joshua Stead
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