Actively Recruiting
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels (SuNDiAL)
Led by Liverpool Women's NHS Foundation Trust · Updated on 2025-09-29
30
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
L
Liverpool Women's NHS Foundation Trust
Lead Sponsor
A
Alder Hey Children's NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the levels of two naturally occurring amino acids, Arginine and Asymmetric Dimethylarginine (ADMA), in newborns undergoing abdominal surgery within the first five days of life due to congenital abdominal malformations. The study aims to understand how the relationship between these amino acids may predict recovery and complications after surgery, based on previous findings in adult patients. This observational, physiological study is conducted across two hospitals within the Liverpool Neonatal Partnership.
CONDITIONS
Brief Title
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants born after 35 weeks gestation
- Infants with a condition requiring major gastrointestinal surgery
- Surgery must occur within the first 5 days (120 hours) after birth
- Parent(s)/guardian(s) must understand written and spoken English sufficiently to provide informed consent
- Parent(s)/guardian(s) must be willing and able to provide informed consent
You will not qualify if you...
- Infants unlikely to survive due to poor immediate postoperative condition
- Infants with a known or suspected inborn error of metabolism or serious liver dysfunction
- Parent(s)/guardian(s) unable to provide informed consent
- Infants from whom the minimum required residual serum samples cannot be obtained from routine blood testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 5 days after surgery or preoperatively
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for consent and eligibility assessment
Duration - Occurs within the first 5 days after birth
Participants undergo major abdominal surgery for congenital gut malformations within the first 5 days of life.
Surgery as per routine clinical care
Duration - Up to 30 days postoperatively or until full recovery (whichever occurs first)
Participants are monitored with routine blood tests and clinical care to assess recovery from surgery.
Routine blood tests with approximately 3 to 5 measurements in the first 10 days post surgery and additional follow-up as per clinical care
Trial Site Locations
Total: 2 locations
1
Alder Hey Childrens Hospital NSH Foundation Trust
Liverpool, Merseyside, United Kingdom, L12 2AP
Actively Recruiting
2
Liverpool Womens Hospital NHS Foundation Trust
Liverpool, Merseyside, United Kingdom, L8 7SS
Actively Recruiting
Research Team
C
Colin Morgan
J
Joshua Stead
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here