Actively Recruiting
Exploratory Study on the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients
Led by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Updated on 2024-10-02
470
Participants Needed
1
Research Sites
98 weeks
Total Duration
On this page
Sponsors
S
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lead Sponsor
A
Amoy Diagnostics
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to retrospectively include 470 initial surgical specimens from 470 patients with epithelial ovarian, fallopian tube or primary peritoneal cancers who were treated with PARPi maintenance therapy in the hospital from 2018.01 to 2024.01. All patients included would be scored by the proprietary HRD ADx-GSS® algorithm with the detecting results of the three genomic statuses including heterozygous omission (LOH), telomere allelic imbalance (TAI), and large-segment translocation (LST). Finally, the correlation between the HRD scores and the prognosis of Chinese ovarian cancer patients and the efficacy of using PARPi as maintenance treatment would be explored.
CONDITIONS
Official Title
Exploratory Study on the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer diagnosed after January 2015 or platinum-sensitive recurrent patients with these cancers treated with PARPi maintenance therapy by January 2024 after chemotherapy
- Female patients aged 18 years or older
- Stable CA125 level, ECOG performance status 0-2, and appropriate heart, liver, and kidney function before using PARPi
You will not qualify if you...
- Other malignancies diagnosed within the past 5 years
- Poor general health including ECOG PS score greater than 2, KPS score less than 60, cardiac insufficiency (Class III-IV), hepatic insufficiency (Child-Pugh Class C), or renal insufficiency (Stage 4-5)
- Insufficient or poor-quality samples for testing
- Any condition judged by the investigator to affect study conduct or result determination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sun Yat-sen memorial hospital
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
J
Jing Li, M.D. Ph.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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