Actively Recruiting
An Exploratory Study of Deep Cervical Lymphovenous Bypass (LVB) in Alzheimer's Disease
Led by Affiliated Hospital of Jiangnan University · Updated on 2024-07-12
30
Participants Needed
1
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main pathological mechanism of Alzheimer's Disease (AD) is the abnormal deposition of amyloid-beta (Aβ) and tau proteins in the brain. Recent studies indicate that these two proteins are primarily cleared through the glymphatic system-meningeal lymphatic vessels-deep cervical lymphatic vessels pathway. Lymphatic circulation disorders in elderly patients can directly lead to the abnormal deposition of these proteins. Deep cervical lymphovenous bypass can improve lymphatic circulation and effectively treat lymphedema. This project aims to verify the effectiveness of 'deep cervical lymphovenous bypass' in treating AD, offering a new surgical treatment method to improve cognitive impairment and the quality of life for AD patients.
CONDITIONS
Official Title
An Exploratory Study of Deep Cervical Lymphovenous Bypass (LVB) in Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 60 and 80 years, diagnosed with Alzheimer's Disease for more than 12 months
- Estimated survival time longer than 12 months
- Clinically diagnosed with mild to severe Alzheimer's Disease
- Imaging tests support the diagnosis
- Voluntary participation with signed informed consent and guardian agreement
You will not qualify if you...
- Having other severe systemic diseases
- Unable to tolerate general anesthesia
- Pregnant women
- Recent severe infections or infectious diseases within the past 4 weeks
- Unable or unwilling to complete one-year clinical follow-up
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Affiliated Hospital of Jiangnan University
Wuxi, Jiangsu, China
Actively Recruiting
Research Team
L
Lu Hua
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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