Actively Recruiting
An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors
Led by Gustave Roussy, Cancer Campus, Grand Paris · Updated on 2025-06-24
160
Participants Needed
1
Research Sites
264 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a study to explore the phenotypic and transcriptional changes of different cellular components in the tumor following the injection of somatic cell therapy drugs. The second objective is to explore phenotypic and transcriptional changes of different cellular components in blood and bone marrow following injection of somatic cell therapy drugs.Then correlate the phenotypic and transcriptional profile of different tumor, blood and bone marrow immune populations with clinical response and/or toxicity. And to finish this study is designed in order to identify a phenotypic, transcriptional and epigenetic profile of intra-tumoral adoptive cells and correlate this profile with clinical response and/or toxicity.
CONDITIONS
Official Title
An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient affiliated to a social security regimen
- Tumor lesion accessible to core biopsies
- Patient who is fully informed, able to comply with the protocol and who signed the informed consent
- Pediatric patients older than 2 years can be included
- No restriction about the Eastern Cooperative Oncology Group (ECOG) status
You will not qualify if you...
- Coagulation abnormality prohibiting a biopsy (patients can still give consent for blood and bone marrow samples)
- Tumor lesion not accessible to core biopsies
- Pregnant or nursing women cannot participate in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Gustave Roussy Cancer Campus Grand Paris
Villejuif, Val De Marne, France, 94805
Actively Recruiting
Research Team
C
Camille BIGENWALD, MD
CONTACT
C
Cristina CASTILLA LLORENTE, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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