Actively Recruiting
An Exploratory Study on Gene Methylation Detection of Colorectal Cancer
Led by Zhejiang Provincial People's Hospital · Updated on 2025-06-29
450
Participants Needed
1
Research Sites
42 weeks
Total Duration
On this page
Sponsors
Z
Zhejiang Provincial People's Hospital
Lead Sponsor
J
Jinjiang Central Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this exploration study is to evaluate the performance of a colorectal cancer (CRC) early screening model based on the DNA methylation technology platform. The study focuses on individuals over the age of 40 and aims to identify and verify methylation biomarkers for colorectal cancer using stool samples . The main question it aims to answer is: Can a DNA methylation-based model effectively detect colorectal cancer and adenoma in individuals over 40 using non-invasive stool samples? Participants will provide stool samples for methylation analysis. The study results will be used solely for internal product performance evaluation and optimization by the sponsor and will not be used for product registration or influence any clinical diagnosis.
CONDITIONS
Official Title
An Exploratory Study on Gene Methylation Detection of Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Sample source includes hospital physical examination, outpatient, and inpatient patients
- Patient information such as age, hospital ID, gender, clinical diagnosis, colonoscopy, and pathology results must be traceable
- Participants must be 40 years old or older
- Stool and plasma samples must be collected within 3 months prior to colonoscopy, with stool samples preferred
You will not qualify if you...
- Samples with unclear collection time or stool samples not collected within 3 months prior to colonoscopy
- Samples that do not meet collection and storage requirements
- History or treatment of colorectal cancer or advanced precancerous lesions
- Samples with insufficient volume for testing
- Diagnosis or family history of hereditary colorectal cancer syndromes such as familial adenomatous polyposis, Lynch syndrome, Peutz-Jeghers syndrome, MYH-associated polyposis, Turcot syndrome, Cowden syndrome, juvenile polyposis, neurofibromatosis, or familial proliferative polyposis
- Diagnosis or personal history of inflammatory bowel disease including chronic ulcerative colitis or Crohn's disease
- Diagnosis of Cronkhite-Canada syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
Z
zhenyuan qian
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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