Actively Recruiting
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Led by National University of Singapore · Updated on 2026-03-06
40
Participants Needed
1
Research Sites
32 weeks
Total Duration
On this page
Sponsors
N
National University of Singapore
Lead Sponsor
D
Danone Global Research & Innovation Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years.
CONDITIONS
Official Title
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Singapore residents of all ethnic groups
- Adults aged 50-80 years, male or female
- Body mass index (BMI) of 18 kg/m² or higher
- Classified as pre-frail according to Fried frailty criteria
- Willing and able to attend all data collection visits and follow study protocols
- Able and willing to provide written informed consent
You will not qualify if you...
- Currently using supplements containing Bifidobacterium longum 536 (BB536) or similar probiotics/prebiotics
- Body mass index (BMI) greater than 30 kg/m²
- Following special diets such as ketogenic or prescribed by a healthcare professional
- Received any vaccination within the past 8 weeks
- Recently started new medications or using medications affecting gastrointestinal function in past 8 weeks, including antibiotics or proton pump inhibitors
- Known allergies or intolerances to soy, fiber, fish, cow's milk protein, lactose, or galactosemia
- Having more than two unstable chronic conditions like hypertension, diabetes, or COPD
- Medical conditions contraindicating probiotic use, including immunocompromised state or severe gastrointestinal issues
- Contraindications to oral feeding such as gastrointestinal failure or intestinal obstruction
- Known renal disease preventing tolerance of two supplement servings per day
- Intake of supplemental calcium over 500 mg/day or vitamin D over 40 µg/day from all sources
- Use of medications that impair absorption of milk products, e.g., tetracyclines
- Any other condition deemed by the investigator to compromise safety or compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
MD11 Clinical Research Centre, #03-01, 10 Medical Drive
Singapore, Singapore, 117597
Actively Recruiting
Research Team
M
Mazzarine Dotou, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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