Actively Recruiting
An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion
Led by Shanghai Mental Health Center · Updated on 2026-05-07
400
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating bipolar disorder (BD), a complex mental health condition with challenging treatment and poor prognosis. This study aims to improve the prediction of BD recurrence by using advanced sentiment analysis technology that combines multiple types of data, such as text, audio, visual cues, eye movements, and electrophysiology. The goal is to develop biological markers and an algorithm model for better risk prediction and to support future clinical decision-making in BD management. The study will enroll 200 participants diagnosed with bipolar disorder according to DSM-5 criteria and 200 healthy controls. Participants will be observed without any intervention, with the collection of multi-modal data to analyze emotional expressions and identify recurrence risk. The research builds on previous neuroimaging and big data studies and uses a prospective cohort design to verify and optimize the prediction model over time. Participants with bipolar disorder will be followed for one year, with assessments every three months to monitor recurrence status, while healthy controls will be assessed only once at baseline. The study involves various evaluations including visual, auditory, and emotional data collection to support the algorithm development. This observational study seeks to offer new methods for predicting bipolar disorder recurrence and enhancing clinical diagnosis and treatment approaches.
CONDITIONS
Brief Title
An Exploratory Study on the Prediction of Recurrence Risk of Bipolar Disorder Using Sentiment Analysis Technology Based on Multi-modal Feature Fusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who have previously met or currently meet the diagnostic criteria for bipolar disorder according to DSM-5, whose condition and treatment are currently stable, and who cooperate with the assessment
- Age 18 years or older and under 65 years
- Han Chinese ethnicity
- Sufficient visual and auditory abilities to complete the necessary examinations for the study
- Understanding the study content and signing the informed consent form; if unable to sign, a relative or guardian may sign on their behalf
- Healthy controls aged 18 years or older and under 65 years
- Healthy controls of Han Chinese ethnicity
- Healthy controls gender matched to the patient group
- Healthy controls with sufficient visual and auditory ability to complete the necessary examinations
- Healthy controls who understand the study content and sign informed consent
- Healthy controls with no family history of mental illness
You will not qualify if you...
- Presence of intellectual disability or other conditions significantly affecting current mental state
- Serious or unstable physical illnesses including neurological disorders, heart conditions, hypertension (untreated or uncontrolled), malignant tumors, immunodeficiency, or blood glucose levels over 12 mmol/L
- Other diseases that may interfere with test assessments (abnormal indicators more than twice normal value)
- Individuals with mental disorders according to DSM-5 or suspicious mental symptoms not meeting diagnostic criteria (for healthy controls)
- Individuals with severe physical illness that makes study examinations difficult (for healthy controls)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to confirm eligibility and obtain consent
Duration - 1 year
Participants with bipolar disorder are followed to assess recurrence risk using sentiment analysis technology.
Quarterly visits every 3 months for up to 1 year
Duration - Single timepoint
Healthy control participants undergo baseline assessments to provide comparison data.
1 visit (in-person) at baseline only
Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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