Actively Recruiting
Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults
Led by Peking University Third Hospital · Updated on 2025-06-27
400
Participants Needed
3
Research Sites
95 weeks
Total Duration
On this page
Sponsors
P
Peking University Third Hospital
Lead Sponsor
T
The First Affiliated Hospital of Nanchang University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to understand whether oral vitamin C can help delay the aging of middle-aged and elderly individuals, search for sensitive biomarkers of human aging, and provide new paradigms and scientific guidance for aging intervention with small molecule drugs. The main questions it aims to answer are as follows: * Can oral vitamin C effectively improve the aging-related indicators? * What is the safety of participants when taking vitamin C supplements? Researchers will compare vitamin C with a placebo to observe whether vitamin C is effective in intervening in the aging of middle-aged and elderly individuals. Participants need to: * Take 2 tablets (250mg/tablet) of vitamin C or placebo after breakfast and dinner every day for 12 consecutive months; * Go to the designated place for a face-to-face follow-up every 6 months and receive a telephone follow-up every 2 months, and pick up subsequent drugs during the follow-up; * Honestly inform the medication situation during each follow-up; * Report any discomfort or adverse reactions that occur during the treatment process to the researchers; * Fill in a questionnaire about their own health status during each follow-up; * After 6 months and 12 months of intervention, conduct a comprehensive health examination as required, including blood tests and other items.
CONDITIONS
Official Title
Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55 to 65 years for experimental and control groups, or 18 to 70 years for baseline control group
- Good health based on medical history, physical exam, lab tests, and cardiac monitoring
- Body mass index (BMI) between 18.5 and 28 kg/m²
- Ability to provide informed consent and follow study requirements
You will not qualify if you...
- Uncontrolled medical conditions or diseases that may interfere with the study
- Severe chronic or acute diseases such as cancer, heart failure, kidney insufficiency, COPD, diabetes, active liver disease, metabolic acidosis, poorly controlled hypertension, epilepsy, recent cardiovascular events, inflammatory bowel disease, neurological or infectious diseases, or severe autoimmune diseases
- BMI less than 18.5 or greater than 28
- Current alcohol or drug abuse or excessive alcohol consumption
- History of gastrointestinal diseases, hyperuricemia, kidney or urinary tract stones, glucose-6-phosphate dehydrogenase deficiency, or paroxysmal nocturnal hemoglobinuria
- Allergy to vitamin C or any component of its formulation
- Use of high-dose vitamin C, vitamin E, low-dose aspirin, acarbose, metformin, NMN/NR, or other anti-aging/weight-loss drugs within the last 3 months
- Inability to provide informed consent
- Any physical condition that may negatively affect the study
- Participation in other clinical research within 3 months prior to screening or during the study, or recent chemotherapy, radiotherapy, biologic therapy, small-molecule therapy, or investigational drug use without full recovery from side effects (excluding alopecia or potential neuropathy)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
The first affiliated hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Actively Recruiting
2
People's Hospital of Quzhou
Quzhou, Zhejiang, China, 324000
Actively Recruiting
3
Peking University Third Hospital
Beijing, China, 100191
Enrolling by Invitation
Research Team
T
Tian Tian
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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