Actively Recruiting
Randomized Controlled Trial on Vitamin C Supplementation for Health Regulation in Middle-Aged and Elderly Adults
Led by Peking University Third Hospital · Updated on 2025-06-27
400
Participants Needed
3
Research Sites
52 weeks
Total Duration
On this page
Sponsors
P
Peking University Third Hospital
Lead Sponsor
T
The First Affiliated Hospital of Nanchang University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether oral vitamin C can help slow aging in middle-aged and elderly adults. The study aims to find sensitive biomarkers of aging and provide scientific guidance for aging interventions using small molecule drugs. Key questions include whether vitamin C improves aging-related indicators and the safety of taking vitamin C supplements. Participants will be randomly assigned to take either vitamin C tablets (500 mg twice daily) or placebo tablets with the same appearance, twice a day after breakfast and dinner for 12 months. A baseline control group of healthy volunteers aged 18 to 70 will not receive any intervention but will be observed for age-related changes. Participants will attend face-to-face follow-ups every 6 months and telephone check-ins every 2 months to report medication use and any adverse effects. They will complete health questionnaires and undergo comprehensive health exams, including blood tests, at 6 and 12 months. Researchers will evaluate aging intervention effectiveness, cognitive and physical function, muscle mass, cardiovascular health, vitamin C levels, and various biological markers over the year.
CONDITIONS
Brief Title
Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55 to 65 years for experimental and control groups; 18 to 70 years for baseline control group
- Good health based on medical history, physical exam, lab tests, and cardiac monitoring
- Body mass index (BMI) between 18.5 and 28 kg/m�b2
- Able to provide informed consent and follow study requirements
You will not qualify if you...
- Uncontrolled medical conditions or diseases posing risk or interfering with study (e.g., cancer, heart failure, renal insufficiency, COPD, diabetes, active liver disease, metabolic acidosis, poorly controlled hypertension, epilepsy, recent cardiovascular events, inflammatory bowel disease, neurological disorders, infectious diseases, severe autoimmune diseases)
- BMI less than 18.5 or greater than 28
- Ongoing alcohol or drug abuse or excessive alcohol consumption
- History of gastrointestinal diseases, hyperuricemia, kidney or urinary tract stones, G6PD deficiency, or paroxysmal nocturnal hemoglobinuria
- Allergy to vitamin C or study tablet components
- Use of high-dose vitamin C, vitamin E, low-dose aspirin, acarbose, metformin, NMN/NR, or other anti-aging/weight-loss drugs within last 3 months
- Unable to provide informed consent
- Any physical condition that may adversely affect study participation or outcomes
- Participation in other clinical research within 3 months prior or during study or incomplete recovery from chemotherapy, radiotherapy, biologic therapy, small molecule agents, or investigational drugs (except alopecia or neuropathy)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 months
Participants take vitamin C tablets or placebo twice a day as part of the study intervention. A baseline control group does not receive any intervention but participates in assessments.
Regular visits for assessments throughout the 12 months
Trial Site Locations
Total: 3 locations
1
The first affiliated hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Actively Recruiting
2
People's Hospital of Quzhou
Quzhou, Zhejiang, China, 324000
Actively Recruiting
3
Peking University Third Hospital
Beijing, China, 100191
Enrolling by Invitation
Research Team
T
Tian Tian
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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