Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients.
Lior Carmi, Uri Alyagon, Noam Barnea-Ygael...
https://pubmed.ncbi.nlm.nih.gov/28927961Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID07587112
Explore Neural Mechanism of OCD by Intervention of Repetitive Transcranial Magnetic Stimulation With Symptom Provocation
Led by Taipei Veterans General Hospital, Taiwan · Updated on 2026-05-14
96
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are investigating how different deep transcranial magnetic stimulation (TMS) coils and brain stimulation targets affect symptoms of obsessive-compulsive disorder (OCD). This study also explores the brain mechanisms behind OCD through detailed brain imaging techniques. Adults aged 18 to 65 diagnosed with OCD are enrolled, and the study uses a double-blind, randomized design to compare outcomes across groups. Participants are randomly assigned to one of three groups: active deep TMS using the H7 coil, active deep TMS using the H1 coil, or a sham (placebo) stimulation group. The treatment phase lasts six weeks, with five sessions per week. Before each session, participants undergo symptom provocation and resting motor threshold measurement. After the treatment, follow-up brain PET/MRI scans and symptom assessments are conducted at two weeks and six months to evaluate changes and plan further treatments. During the study, participants complete symptom severity interviews every two weeks and brain scans before and after treatment. Researchers monitor adverse effects and treatment expectations. The main outcome measured is the percentage change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores after 6 and 8 weeks. Brain imaging analyses examine functional connectivity and glucose metabolism changes to understand neural network alterations. Participants continue regular outpatient follow-up after the study ends.
CONDITIONS
Brief Title
Explore Neural Mechanism of OCD by Intervention of Repetitive Transcranial Magnetic Stimulation With Symptom Provocation
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- Diagnosis of obsessive-compulsive disorder according to DSM-5 criteria
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of 14 or higher indicating mild to moderate symptom severity
You will not qualify if you...
- Diagnosis of schizophrenia, organic psychotic disorder, bipolar disorder, alcohol use disorder, or substance use disorder
- High suicide risk within the past year
- Significant active medical or surgical conditions
- History of or planned neurosurgical procedures or presence of metallic implants in the brain or body
- Structural brain abnormalities or neurological disorders such as meningitis, encephalitis, stroke, or epilepsy
- Pregnant women
- Inability to tolerate PET/MRI due to claustrophobia or severe anxiety
- Conditions impairing study compliance or inability to provide informed consent
- Use of medications increasing seizure or suicide risk
- Known allergy to 18F-FDG
- History of adverse reaction to TMS or allergy to the positioning cap
- Presence of metallic objects near the cranial region
- Prior or current electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS) treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - 6 to 8 weeks
Participants receive repetitive transcranial magnetic stimulation using either sham deep TMS or active deep TMS with H7 or H1 coils.
Multiple visits during the treatment period
Trial Site Locations
Total: 1 location
1
Taipei Veterans General Hospital
Taipei, Taiwan
Actively Recruiting
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Research Team
C
Cheng-Ta Li
C
Chia-Min Huang
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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