Study of Topical Capsaicin Patch to Relieve Pain and Improve Walking in Adults with Chemotherapy-Induced Peripheral Neuropathy

What this Trial Is About

Researchers are evaluating whether topical capsaicin can help relieve pain caused by chemotherapy-induced peripheral neuropathy CIPN and improve walking patterns in affected patients. This early-phase study focuses on supportive care for patients experiencing chronic lower extremity pain from CIPN due to specific chemotherapy drugs. The study aims to explore changes in gait velocity, pain intensity, sensory testing results, and nerve fiber integrity with the use of capsaicin. Participants will apply up to four topical capsaicin patches to their feet for 30 minutes. The study monitors multiple outcomes including pain intensity ratings, quantitative sensory testing, nerve integrity via optional skin biopsies, pain assessment scales, and patient impressions of change. Researchers will also track any adverse events or side effects related to the capsaicin patches throughout the study period. Participants will undergo assessments before and after treatment to evaluate changes in gait and pain levels. Measurements include numerical pain ratings, sensory tests, pain interference questionnaires, and optional skin biopsies. Safety and tolerability are carefully monitored over about one year. The total participation time spans from enrollment through study completion, with ongoing evaluation of adverse events and patient-reported outcomes.

Exploring the Benefit of Topical Capsaicin in Treating Pain From Chemo-induced Peripheral Neuropathy: a Longitudinal Single Center Pilot Study