Actively Recruiting
Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension
Led by University Hospital, Strasbourg, France · Updated on 2025-09-16
120
Participants Needed
1
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to understand how blood cell (including peripheral blood mononuclear cells ((PBMCs) or platelets) function and oxidative stress can help physicians detect and predict the course of pre-capillary pulmonary hypertension. We hypothesize that changes in the mitochondrial function of blood cells and oxidative stress may be early markers of disease progression and severity. The study will also explore how these blood markers relate to routine clinical and heart function measurements, such as echocardiography, right heart catheterization, 6-minute walk tests, and functional status, to see if they can help monitor patients over time and guide personalized care. This is a non-interventional study. Blood samples will be collected during routine visits planned for diagnosis and follow-up. The study will include 120 patients diagnosed with pre-capillary pulmonary hypertension, who will be followed for 3 years. Blood samples will be taken up to three times per year to measure mainly oxidative stress and mitochondrial function in blood cells. These measurements will be compared with clinical tests to see if they can help predict the course of the disease.
CONDITIONS
Official Title
Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
- Patients classified as Group 1 (pulmonary arterial hypertension), Group 3 (pulmonary hypertension with chronic respiratory diseases or hypoxia), or Group 4 (chronic thromboembolic pulmonary hypertension)
- Patients scheduled for routine clinical follow-up and/or right heart catheterization at the study center
- Ability and willingness to provide informed consent for participation and data analysis
You will not qualify if you...
- Postcapillary pulmonary hypertension (pulmonary arterial wedge pressure >15 mmHg)
- Conditions preventing safe blood sampling such as severe anemia or coagulopathy
- Enrollment in interventional clinical trials that might affect mitochondrial or oxidative stress measurements
- Inability or unwillingness to provide informed consent
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpitaux Universitaires de Strasbourg - Service Physiologie explorations fonctionnelles
Strasbourg, Bas-Rhin, France, 67000
Actively Recruiting
Research Team
M
Marianne RIOU
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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