Actively Recruiting
Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
Led by Fondazione Italiana Linfomi - ETS · Updated on 2025-12-29
200
Participants Needed
20
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma or High-Grade B-cell Lymphoma
CONDITIONS
Official Title
Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of nodal and extranodal Diffuse Large B Cell Lymphoma or High Grade B Cell Lymphoma (including low-grade transformed, double and triple hit, 11q aberration, not otherwise specified) after January 1, 2019
- Presence of one MYC translocation or gain of copies (more than 3 copies in over 30% of nuclei) or amplification evaluated by FISH
- Availability of immunohistochemical analysis for CD10, Bcl6, MUM1, Bcl2, Myc, Ki67
- Have received curative first-line treatment such as R-CHOP, R DA EPOCH, or intensified "Burkitt like" chemotherapy
- Histological material of adequate size and quality for review and additional testing; FFPE block must be provided
- Age between 18 and 79 years
You will not qualify if you...
- Primary lymphomas of the central nervous system, plasmablastic lymphoma, Burkitt's lymphoma, or primary mediastinal B lymphoma
- Have received palliative treatment
AI-Screening
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Trial Site Locations
Total: 20 locations
1
A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia
Alessandria, Italy
Actively Recruiting
2
A.O.U. Ospedali Riuniti delle Marche - Clinica di Ematologia
Ancona, Italy
Actively Recruiting
3
I.R.C.C.S. Istituto Tumori Giovanni Paolo II - U.O.C. Ematologia
Bari, Italy
Actively Recruiting
4
ASST Spedali Civili - S.C. Ematologia
Brescia, Italy
Actively Recruiting
5
I.R.C.C.S. Istituto di Candiolo - FPO
Candiolo, Italy
Actively Recruiting
6
I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncoematologia
Castelfranco Veneto, Italy
Not Yet Recruiting
7
ARNAS Garibaldi - U.O.C. Ematologia
Catania, Italy
Actively Recruiting
8
A.S.T. Macerata - U.O.S.D Ematologia
Civitanova Marche, Italy
Actively Recruiting
9
Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia
Florence, Italy
Actively Recruiting
10
ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia
Milan, Italy
Actively Recruiting
11
Ospedale Maggiore Policlinico Fondazione IRCCS Ca' Granda - S.C. Ematologia
Milan, Italy
Actively Recruiting
12
A.O.U. di Padova - U.O.C. Ematologia
Padova, Italy
Not Yet Recruiting
13
I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1
Padova, Italy
Not Yet Recruiting
14
AUSL Modena sede di Sassuolo - UOSD di Oncologia Area Sud
Sassuolo, Italy
Actively Recruiting
15
U.O.C. Ematologia - A.O.U. Senese
Siena, Italy
Not Yet Recruiting
16
A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U
Torino, Italy
Not Yet Recruiting
17
ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia
Treviso, Italy
Actively Recruiting
18
A.O. Cardinale "G. Panico" - U.O.C Ematologia e Trapianto Midollo Osseo
Tricase, Italy
Actively Recruiting
19
A.S.U. Giuliano Isontina - S.C. Ematologia
Trieste, Italy
Actively Recruiting
20
A.O.U.I. di Verona - Ematologia
Verona, Italy
Not Yet Recruiting
Research Team
U
Uffici Studi FIL
CONTACT
U
Uffici Studi FIL
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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