Actively Recruiting
Exploring Cortical Remyelination in Children With Multiple Sclerosis
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-03-06
40
Participants Needed
3
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.
CONDITIONS
Official Title
Exploring Cortical Remyelination in Children With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 12 and 18 years old
- Diagnosis of relapsing-remitting multiple sclerosis (RR-MS) based on 2017 McDonald criteria
- No relapse in the last 4 weeks
- No use of methylprednisolone or prednisolone in the last 4 weeks
- Affiliated with the social security system
- Consent signed by both holders of parental authority
- For volunteers: age between 12 and 18 years old
- For volunteers: absence of any neurological condition
- For volunteers: consent signed by both holders of parental authority
You will not qualify if you...
- Parental refusal to participate
- Contraindications to brain MRI such as pacemaker, facial tattoo, or claustrophobia
- Pregnancy
- Use of a copper intrauterine device
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Service de Neurologie Pédiatrique, Hôpital du Kremlin Bicêtre
Le Kremlin-Bicêtre, France, 94270
Actively Recruiting
2
CIC Neurosciences - Pitié Salpêtrière
Paris, France, 75013
Actively Recruiting
3
Service de Neurologie, GH Pitié Salpêtrière
Paris, France, 75013
Not Yet Recruiting
Research Team
E
Elisabeth Maillart, MD, PH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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