Study to Understand How Viral Infections Affect Adults with Chronic Lung Diseases Like COPD and Bronchiectasis

What this Trial Is About

Researchers are exploring how viral infections affect people with chronic lung diseases such as COPD and bronchiectasis. The study aims to better understand the role viruses play in triggering flare-ups, called exacerbations, and how the immune system responds. This is important because viral infections may be a key cause of these worsening episodes, and the study will follow participants for up to two years to learn more about these effects. Participants will attend a baseline visit when they are stable, where clinical information, lung function tests, questionnaires, and various biological samples like sputum, nasal swabs, blood, stool, and exhaled breath will be collected. During flare-ups, participants will collect and send samples from home and attend in-person visits for further assessments and sampling. The study also includes yearly follow-up visits for two years to monitor participants health and disease progression. Throughout the study, participants will keep daily symptom diaries to capture all flare-ups, including mild ones. Researchers will analyze samples to detect respiratory viruses during exacerbations and compare symptoms from viral and non-viral flare-ups. Participants will have clinical reviews, lung function tests, and health questionnaires at scheduled visits. The study aims to provide detailed information on how viral infections influence chronic lung disease and recovery from exacerbations.

Exploring How Viral Infections Affect People With Chronic Lung Disease