Actively Recruiting
Prospective Cohort Study to Understand Impact of Viral Infection in Chronic Lung Disease
Led by Imperial College London · Updated on 2025-07-14
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring how viral infections affect people with chronic lung diseases such as COPD and bronchiectasis. The study aims to better understand the role viruses play in triggering flare-ups, called exacerbations, and how the immune system responds. This is important because viral infections may be a key cause of these worsening episodes, and the study will follow participants for up to two years to learn more about these effects. Participants will attend a baseline visit when they are stable, where clinical information, lung function tests, questionnaires, and various biological samples like sputum, nasal swabs, blood, stool, and exhaled breath will be collected. During flare-ups, participants will collect and send samples from home and attend in-person visits for further assessments and sampling. The study also includes yearly follow-up visits for two years to monitor participants' health and disease progression. Throughout the study, participants will keep daily symptom diaries to capture all flare-ups, including mild ones. Researchers will analyze samples to detect respiratory viruses during exacerbations and compare symptoms from viral and non-viral flare-ups. Participants will have clinical reviews, lung function tests, and health questionnaires at scheduled visits. The study aims to provide detailed information on how viral infections influence chronic lung disease and recovery from exacerbations.
CONDITIONS
Brief Title
Exploring How Viral Infections Affect People With Chronic Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with a doctor-confirmed diagnosis of chronic airway disease such as COPD or bronchiectasis
- History of at least one exacerbation in the past year requiring antibiotics or corticosteroids
You will not qualify if you...
- Unable to complete daily symptom diaries or attend clinical visits
- Experiencing an exacerbation or clinical instability within 4 weeks before joining the study
- Pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 years with assessments at 12-month intervals
Participants who are clinically stable undergo baseline and follow-up clinical visits to assess respiratory function, symptoms, and collect biological samples.
1 baseline visit and annual visits for 2 years (in-person)
Duration - Throughout the 24-month follow-up period
Participants record daily symptoms and are monitored for exacerbations. Sampling and clinical assessments occur remotely and in-person during exacerbation episodes.
Remote sampling at early exacerbation and recovery; 1 in-person visit mid-exacerbation
Trial Site Locations
Total: 1 location
1
Royal Brompton Hospital
London, United Kingdom
Actively Recruiting
Research Team
P
Patrick Senior
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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