Actively Recruiting
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
Led by Dr. Asma Abdus Salam · Updated on 2026-04-15
263
Participants Needed
1
Research Sites
95 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to identify the genes as well as their association with Nalbuphine. This will help the investigator to identify opioid vulnerability in Pakistani population in the postoperative patients and will contribute to overcoming the opioid crisis, resulting in better and safer outcomes. Research question is: Is there any association between the underlying genetic variations and the analgesic efficacy of Nalbuphine in postoperative patients? The Research Objectives are 1. To identify the underlying genes in postoperative patients having pain. 2. To find an association between identified genes and nalbuphine clinical efficacy. Procedure: After the written informed consent adult men and women will be enrolled in the study. On the day of surgery in the preoperative area, a 5 ml blood sample will be drawn before surgery and will be sent to laboratory for analysis. After routine hemodynamic monitoring in the operative room, general anesthesia will be given including nalbuphine. Standard routine anesthesia monitoring will be done and maintained while monitoring heart rate, ECG, NIBP oxygen saturation, ETCO2 and temperature. Incremental analgesia will be provided whenever needed. After extubation and shifting to recovery room the 2nd sample of blood will be taken and will be sent for analysis. Pain score, nausea vomiting, sedation, requirement of analgesia will be assessed till 24 hours postoperatively.
CONDITIONS
Official Title
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult men or women aged 18 to 70 years
- ASA physical status classification 1, 2, or 3
- Undergoing abdomino-pelvic surgeries lasting 2 to 4 hours, including open hernia repair, appendectomy, open cholecystectomy, laparotomy, hysterectomy, or cystectomy
You will not qualify if you...
- Surgical procedures lasting more than 4 hours
- Use of fluconazole, warfarin, clopidogrel, amitriptyline, rifampicin, or buprenorphine
- History of allergy or hypersensitivity to opioids
- Pregnant or breastfeeding women
- History of narcotic dependency, addiction, or withdrawal
- Complications during surgery requiring intensive care
- Refusal to participate
- Use of other intraoperative analgesia methods such as epidural analgesia or nerve blocks
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ziauddin University
Karachi, Sindh, Pakistan, 755000
Actively Recruiting
Research Team
A
Asma Abdus Salam, FCPS, MCPS, MBBS
CONTACT
Z
Zulfiqar Omrani, Director ORIC
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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