Genetic Testing for Opioid Pain Management: A Primer.
Deepti Agarwal, Mercy A Udoji, Andrea Trescot
https://pubmed.ncbi.nlm.nih.gov/28409480Actively Recruiting
Phase 2
Phase 3
Age: 18Years - 70Years
All Genders
ID06996561
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
Led by Dr. Asma Abdus Salam · Updated on 2026-04-15
263
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how genetic differences affect the pain relief provided by nalbuphine in adults undergoing certain abdominal and pelvic surgeries. This trial aims to identify genes linked to pain and how they influence nalbuphine's effectiveness in postoperative patients, focusing on a Pakistani population to help address opioid use challenges and improve pain management. Participants will receive nalbuphine intravenously during surgery, with doses given at induction and as needed based on heart rate and blood pressure. Standard anesthesia with propofol, atracurium, oxygen, nitrous oxide, and isoflurane will be used. Blood samples will be taken before surgery and after extubation for genetic analysis, focusing on patients with persistent pain or opioid side effects. Pain, sedation, nausea, vomiting, and analgesic needs will be monitored for 24 hours after surgery. Participants will be assessed through vital sign monitoring during surgery and pain and sedation evaluations for 24 hours after. Blood samples will be analyzed genetically to explore links between genes and nalbuphine response. Researchers will measure pain scores as the main outcome and track sedation, nausea, vomiting, and additional pain medication use. The study will follow participants from before surgery through 24 hours postoperatively to understand nalbuphine's clinical effects and genetic influences.
CONDITIONS
Brief Title
Exploring the Impact of Genetic Variations on The Clinical Efficacy of Nalbuphine in Postoperative Pain Management
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult men or women aged 18 to 70 years
- ASA physical status classification 1, 2, or 3
- Undergoing abdomino-pelvic surgeries such as open hernia repair, appendectomy, open cholecystectomy, laparotomy, hysterectomy, or cystectomy
- Surgical procedure lasting between 2 and 4 hours
You will not qualify if you...
- Surgical procedure lasting more than 4 hours
- Taking antifungal fluconazole, anticoagulants like warfarin or clopidogrel, SNRI (amitriptyline), rifampicin, or buprenorphine
- History of allergy or hypersensitivity to opioids
- Pregnant or breastfeeding women
- History of narcotic dependency, addiction, or withdrawal
- Experiencing adverse side effects or complications during surgery requiring intensive care
- Refusal to participate in the study
- Use of other intraoperative analgesia methods such as epidural analgesia or nerve blocks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Surgery duration plus 24 hours postoperatively
Participants receive nalbuphine intravenously during surgery and intermittently as needed for pain control. Pain and sedation levels are monitored for 24 hours after surgery.
1 surgical procedure and monitoring for 24 hours postoperatively
Sample Collection
Duration - During surgery (half an hour before extubation)
Blood samples are collected from participants half an hour before extubation during surgery for genetic analysis. Only selected samples based on pain response are sent for whole exome sequencing.
1 blood draw (in-person)
Trial Site Locations
Total: 1 location
1
Ziauddin University
Karachi, Sindh, Pakistan, 755000
Actively Recruiting
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Research Team
A
Asma Abdus Salam, FCPS, MCPS, MBBS
Z
Zulfiqar Omrani, Director ORIC
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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