Actively Recruiting

Age: 18Years - 40Years
All Genders
NCT06430775

Exploring Prolonged AMR in ACL Reconstructed Patients

Led by University Ghent · Updated on 2024-07-01

190

Participants Needed

1

Research Sites

132 weeks

Total Duration

On this page

Sponsors

U

University Ghent

Lead Sponsor

R

Research Foundation Flanders

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are: 1\. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint. 2\. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients. 3\. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and/or postsurgical pain levels may exhibit a higher degree of long-lasting AMR. 4\. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR. Participants will: * Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery: * Demopgraphical information * Knee Injury and Osteoarthritis Outcome Score (KOOS) * Lysholm Score (only question 1) * Tegner Activity Scale (current activity level, pre-injury activity level and desired activity level after recovery) * Numeric Rating Score (NRS) for pain levels during the day \& during the night * ACL-Return to Sport after Injury Scale (ACL-RSI) * Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.

CONDITIONS

Official Title

Exploring Prolonged AMR in ACL Reconstructed Patients

Who Can Participate

Age: 18Years - 40Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Be between 18 and 40 years old
  • Have suffered an ACL rupture
  • Undergoing surgical ACL reconstruction at AZ Delta hospital in Roeselare (Campus Brugsesteenweg)
Not Eligible

You will not qualify if you...

  • Have had revision ACL reconstruction surgery
  • Have had other severe lower limb injuries within the past year
  • Have muscular or neurological disorders affecting lower limb function
  • Have fibromyalgia or chronic fatigue syndrome

AI-Screening

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Trial Site Locations

Total: 1 location

1

AZ Delta Hospital (Campus Brugsesteenweg)

Roeselare, West-Vlaanderen, Belgium, 8800

Actively Recruiting

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Research Team

E

Erik Witvrouw, prof. dr.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Exploring Prolonged AMR in ACL Reconstructed Patients | DecenTrialz