Actively Recruiting
Exploring the Recovery Function of Sleep in Neurodegeneration
Led by University of Zurich · Updated on 2022-06-02
200
Participants Needed
1
Research Sites
220 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard to the conception of future intervention studies. To this end, the investigators will follow an exploratory approach in a preferably broad data set collected in patients with neurodegenerative diseases associated with abnormal protein aggregation and in healthy humans.
CONDITIONS
Official Title
Exploring the Recovery Function of Sleep in Neurodegeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Good general health or confirmed diagnosis of neurodegenerative disease associated with abnormal protein aggregation along international criteria
- Age above 18 years
- In ambulant setting: ability to apply the ambulant EEG device for the duration of the study, either alone or with help of co-habitant if MoCA < 20
You will not qualify if you...
- Failure to give informed consent
- Inability to follow the procedures of the study, e.g. due to language problems or cognitive deficits
- Known or suspected non-compliance, drug- or medication abuse
- Inability to hear the tones to be applied during sleep in auditory stimulation experiments
- Skin disorders/problems/allergies in face/ear area that could worsen with electrode application
- Regular intake of drugs that may alter the relationship between sleep and outcome variables under investigation (opioids, benzodiazepines and z-drugs (nonbenzodiazepines))
- Clinically significant concomitant disease states
- Too high (disease) burden for patients
- Additional non-medical exclusion criteria may be defined for certain cognitive tasks (e.g. no glasses during experiments involving eye tracking)
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Zurich, Neurology department
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
A
Angelina Maric, Dr. phil.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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