Actively Recruiting
Exploring the Recovery Function of Sleep in Neurodegeneration - an Observational Cross-Sectional Study
Led by University of Zurich · Updated on 2022-06-02
200
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the recovery function of sleep in people with neurodegenerative diseases linked to abnormal protein buildup, as well as in healthy individuals for comparison. The goal is to find the best way to measure how sleep affects brain and behavioral recovery, which may guide future treatment studies. This exploratory study focuses on the connection between sleep quality, cognitive performance, mood, and sleepiness in these patients. Participants will experience either auditory stimulation during sleep or a sham condition where no tones are played but brain activity is still recorded. This randomized, double-blind study includes four nights of sleep monitoring using EEG to measure brain activity. Behavioral and cognitive tasks will be performed before and after the sleep sessions to assess changes. The study also examines subjective sleep quality and mood changes. Participants will apply ambulant EEG devices during the study, either by themselves or with help if cognitive impairment is present. Researchers will collect data on electrophysiological brain markers during sleep, behavioral and cognitive performance, and subjective measures such as sleep quality and mood. Additional physiological measures during sleep and tasks will also be recorded. The study aims to provide a detailed understanding of sleep's role in neurodegenerative conditions over the course of four monitored nights.
CONDITIONS
Brief Title
Exploring the Recovery Function of Sleep in Neurodegeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Good general health or confirmed diagnosis of neurodegenerative disease associated with abnormal protein aggregation according to international criteria
- Age above 18 years
- Ability to apply the ambulant EEG device for the duration of the study, either alone or with help if cognitive assessment MoCA score is below 20
You will not qualify if you...
- Failure to give informed consent
- Inability to follow study procedures due to language problems or cognitive deficits
- Known or suspected non-compliance, drug or medication abuse
- Inability to hear tones applied during sleep in auditory stimulation experiments
- Skin disorders, problems, or allergies in the face or ear area that could worsen with electrode application
- Regular use of drugs that may affect sleep or study outcomes such as opioids, benzodiazepines, or z-drugs
- Clinically significant other diseases
- Too high disease burden for patients
- Additional non-medical exclusions may apply for certain cognitive tasks, such as not wearing glasses during eye-tracking experiments
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 4 nights
Participants undergo auditory stimulation or sham stimulation during sleep in a crossover design.
4 overnight visits (in-person or ambulant EEG device use)
Duration - 4 nights
Participants crossover to the other stimulation condition (verum or sham) delivered during sleep.
4 overnight visits (in-person or ambulant EEG device use)
Trial Site Locations
Total: 1 location
1
University Hospital Zurich, Neurology department
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
A
Angelina Maric, Dr. phil.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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