Actively Recruiting
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease
Led by McMaster University · Updated on 2024-05-21
60
Participants Needed
1
Research Sites
345 weeks
Total Duration
On this page
Sponsors
M
McMaster University
Lead Sponsor
S
St. Joseph's Healthcare Hamilton
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.
CONDITIONS
Official Title
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 85 years with diagnosed lung disease including asthma, emphysema, COPD, bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, eosinophilic granulomatosis with polyangiitis, or bronchopulmonary dysplasia
- Understands the study procedures and agrees to participate with informed consent
- Judged to be in stable health based on medical history
- Able to read and/or understand English
- For healthy volunteers: male or female aged 18 to 85 years with no current or previous history of respiratory infection or disease
You will not qualify if you...
- Age under 18 years or over 85 years
- Pregnancy before or during the study
- Mentally or legally incapacitated individuals unable to provide informed consent or understand written materials
- Unable to perform spirometry or plethysmography tests
- Presence of implanted mechanical, electrical, or magnetic devices or metal in the body that cannot be removed, such as pacemakers or aneurysm clips
- Physical or psychological conditions preventing MRI, including severe claustrophobia
- For healthy volunteers: current or former smokers with 10 or more pack-years, or any history of respiratory infection or disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Firestone Institute for Respiratory Health, St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
Research Team
S
Sarah Svenningsen, PhD
CONTACT
M
Melanie Kjarsgaard, RRT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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