Study of Epithelial-Mesenchymal Transition Markers in Peri-implant Tissues of Patients With Peri-implantitis Compared to Healthy Controls

What this Trial Is About

Researchers are investigating peri-implantitis, a bacterial inflammation causing bone loss and mucous membrane inflammation around dental implants. The study focuses on the role of epithelial-mesenchymal transition EMT, a process where epithelial cells change into motile mesenchymal cells. EMT markers like E-cadherin and vimentin are studied for their involvement in the breakdown of the epithelial barrier in peri-implant tissues, which may contribute to peri-implant disease progression. The study compares peri-implant tissues from two groups patients with peri-implantitis and patients with healthy implants undergoing implant surgery. Tissue samples are collected through biopsies after local anesthesia. Diseased tissue is removed from affected implant sites in the peri-implantitis group, while soft tissue around newly placed implants is sampled in the control group after a two-month healing period. The tissue samples will be analyzed for EMT markers and transcription factors. Participants undergo clinical assessments including probing pocket depth, bleeding on probing, and radiographic bone level measurements before tissue harvesting. Immunohistochemical analysis will evaluate the expression of EMT-related markers. Patients must consent and attend follow-up visits to take part. The study aims to better understand EMTs role in peri-implant disease and its effects on tissue integrity.

Expression of Epithelial-Mesenchymal Transition Associated Markers in Peri-implant Tissues