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Expression of Epithelial-Mesenchymal Transition (EMT) Markers in Peri-implant Tissues From Patients With Peri-implantitis: A Case-Control Study
Led by University of Baghdad · Updated on 2024-08-20
40
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating peri-implantitis, a bacterial inflammation causing bone loss and mucous membrane inflammation around dental implants. The study focuses on the role of epithelial-mesenchymal transition (EMT), a process where epithelial cells change into motile mesenchymal cells. EMT markers like E-cadherin and vimentin are studied for their involvement in the breakdown of the epithelial barrier in peri-implant tissues, which may contribute to peri-implant disease progression. The study compares peri-implant tissues from two groups: patients with peri-implantitis and patients with healthy implants undergoing implant surgery. Tissue samples are collected through biopsies after local anesthesia. Diseased tissue is removed from affected implant sites in the peri-implantitis group, while soft tissue around newly placed implants is sampled in the control group after a two-month healing period. The tissue samples will be analyzed for EMT markers and transcription factors. Participants undergo clinical assessments including probing pocket depth, bleeding on probing, and radiographic bone level measurements before tissue harvesting. Immunohistochemical analysis will evaluate the expression of EMT-related markers. Patients must consent and attend follow-up visits to take part. The study aims to better understand EMT's role in peri-implant disease and its effects on tissue integrity.
CONDITIONS
Brief Title
Expression of Epithelial-Mesenchymal Transition Associated Markers in Peri-implant Tissues
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- For test group: at least one dental implant in function for more than 12 months with clinical diagnosis of peri-implantitis including probing pocket depth of 6 mm or more, bleeding on probing and/or suppuration, radiographic bone loss of 3 mm or more from the first implant thread, and visible signs of inflammation
- For control group: adult patients with one or more missing adjacent teeth in the posterior maxilla or mandible suitable for implant placement of 4.5-5.0 mm diameter and 8.5-13 mm length
- Keratinized mucosa width of at least 3 mm for control group
- Willingness to provide written consent and attend follow-up visits
You will not qualify if you...
- For test group: history of chronic diseases such as diabetes mellitus
- Current smokers
- Pregnant or lactating women
- Received peri-implant surgical therapy within 6 months before tissue sampling
- Received antimicrobial therapy (systemic or local) within 3 months before tissue sampling
- For control group: medical conditions contraindicating implant surgery
- Local inflammation including untreated periodontitis
- Post-extraction sites with less than 6 weeks of healing
- Persistent intraoral infection
- Absence of keratinized tissue
- History of chronic diseases such as diabetes mellitus
- Current or former smokers
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single day procedure
Participants undergo a biopsy procedure to collect peri-implant tissue samples for analysis depending on whether they belong to the peri-implantitis group or the control group undergoing implant surgery.
1 visit (in-person)
Duration - Approximately 2 months
Participants in the control group return approximately 2 months after implant placement for sample harvesting and healing abutment replacement to ensure proper tissue healing.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Talib A. Alnajaty
Karbala, Iraq, 56001
Actively Recruiting
Research Team
T
Talib A Alnajaty
T
Talib A Alnajaty
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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