Study of Gene Expression Linked to Hypertension and Testing 4-7-8 Breathing to Lower Blood Pressure in Adults with Hypertension in Thailand

What this Trial Is About

Researchers are investigating genetic factors related to hypertension in Thailand and evaluating breathing techniques to reduce blood pressure in people with hypertension. The study includes two parts one exploring the expression of specific genes and inflammation markers in individuals from various Thai regions, and another assessing the effect of different breathing exercises on blood pressure in hypertensive volunteers. This research aims to better understand hypertension development and test breathing methods as possible non-drug interventions. In the first part, 200 participants aged 18 to 59 from Thailands eastern region will provide blood samples to measure gene expression and inflammation markers. In the second part, 75 volunteers with hypertension from the first group will be randomly assigned to one of four groups no breathing training, 4-7-8 breathing technique, deep diaphragmatic breathing, or slow breathing using a resistance device. Those practicing breathing exercises will follow their assigned programs daily for three months. Participants will undergo blood pressure and inflammation marker assessments at the start and end of the three-month breathing program. Blood samples will be analyzed for gene expression and inflammatory proteins. The study monitors systolic and diastolic blood pressure, blood pressure variability, and inflammation levels. Overall participation spans from initial blood collection to completing the breathing intervention and final assessments, ensuring detailed evaluation of genetic and physiological changes.

Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure