Actively Recruiting
Expression of Genes Relating Hypertension in Thailand and the Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure in Individuals With Hypertension
Led by Burapha University · Updated on 2026-05-11
200
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating genetic factors related to hypertension in Thailand and evaluating breathing techniques to reduce blood pressure in people with hypertension. The study includes two parts: one exploring the expression of specific genes and inflammation markers in individuals from various Thai regions, and another assessing the effect of different breathing exercises on blood pressure in hypertensive volunteers. This research aims to better understand hypertension development and test breathing methods as possible non-drug interventions. In the first part, 200 participants aged 18 to 59 from Thailand's eastern region will provide blood samples to measure gene expression and inflammation markers. In the second part, 75 volunteers with hypertension from the first group will be randomly assigned to one of four groups: no breathing training, 4-7-8 breathing technique, deep diaphragmatic breathing, or slow breathing using a resistance device. Those practicing breathing exercises will follow their assigned programs daily for three months. Participants will undergo blood pressure and inflammation marker assessments at the start and end of the three-month breathing program. Blood samples will be analyzed for gene expression and inflammatory proteins. The study monitors systolic and diastolic blood pressure, blood pressure variability, and inflammation levels. Overall participation spans from initial blood collection to completing the breathing intervention and final assessments, ensuring detailed evaluation of genetic and physiological changes.
CONDITIONS
Brief Title
Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 to 59 years
- Of Thai ethnicity
- Originally from various regions of Thailand and currently residing in the eastern region
- For hypertensive group: diagnosed with hypertension (SBP ≥140 mmHg or DBP ≥90 mmHg) or taking antihypertensive medication
- For normal blood pressure group: SBP below 130 mmHg and DBP below 85 mmHg with no hypertension diagnosis or medication
- For breathing intervention: aged 35 to 59 years, diagnosed with hypertension (SBP ≥130 mmHg or DBP ≥85 mmHg), currently taking medication, and able to communicate effectively
You will not qualify if you...
- Having heart disease such as valvular stenosis, regurgitation, coronary artery disease, or heart failure
- Obesity with BMI of 30 kg/m² or higher
- Having fever or current infectious disease (e.g., COVID-19, flu)
- Having respiratory, cardiovascular, cerebrovascular, kidney disease, cancer, or immune-related conditions like allergies, autoimmune diseases, immunodeficiency, or rheumatoid arthritis
- Currently pregnant, breastfeeding, or pregnancy within 6 months prior to participation (for breathing intervention)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide blood samples to assess gene expression and inflammation markers, and have blood pressure measured before any intervention begins.
1 visit (in-person)
Duration - 3 months
Participants in the breathing intervention groups follow their assigned breathing programs daily for three consecutive months. The control group does not receive breathing training.
Daily breathing practice with no required visits during treatment
Duration - 1 day
Participants have blood pressure measured and blood samples collected again to assess changes in gene expression, inflammation markers, and blood pressure variability after the breathing interventions.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Faculty of Allied Health Sciences, Burapha University
MueangChonburi, Changwat Chon Buri, Thailand, 20131
Actively Recruiting
Research Team
P
Piyapong Prasertsri, Ph.D.
T
Tadsawiya Padkao, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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