Actively Recruiting
Extended Depth of Focus (EDF) Intraocular Lens (IOL) Versus Monofocal Intracoular Lens (IOL)
Led by Carl Zeiss Meditec AG · Updated on 2026-03-12
220
Participants Needed
14
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Extended depth of focus (EDF) intraocular lens (IOL) versus Monofocal intraocular lens (IOL)
CONDITIONS
Official Title
Extended Depth of Focus (EDF) Intraocular Lens (IOL) Versus Monofocal Intracoular Lens (IOL)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of any gender aged 18 years or older
- Clinically significant bilateral age-related cataracts planned for phacoemulsification cataract extraction and eligible for posterior chamber intraocular lens implantation
- Preoperative corneal astigmatism of 1.00 diopter or less
- Calculated lens power within the available range
- Clear intraocular media other than cataract
- Willing and able to provide informed consent
- Willing and able to comply with study visits and procedures
You will not qualify if you...
- Preoperative corrected distance visual acuity better than 0.3 logMAR (0.5 decimal)
- Endothelial cell count less than 2000/mm2
- Acute, chronic, or uncontrolled systemic disease increasing operative risk or confounding outcomes
- Ocular conditions that may cause visual acuity of 0.2 logMAR or worse during the study
- Clinically significant corneal abnormalities or dystrophies
- Previous intraocular or corneal/refractive surgery that may affect outcomes or increase risk
- Conditions affecting intraocular lens stability
- Diagnosed degenerative visual disorders or other eye pathologies predicting poor visual acuity
- Current systemic or ocular medications with significant ocular side effects
- Clinically significant gonioscopic abnormalities
- Amblyopia, strabismus, or single eye status
- Rubella, congenital, traumatic, or complicated cataracts
- History or current anterior or posterior segment inflammation
- Microphthalmos or macrophthalmos
- Pupil abnormalities
- Pseudoexfoliation
- Keratoconus or irregular astigmatism
- Inability to measure keratometry or biometry
- Pathologic miosis
- Pregnancy, planned pregnancy, or lactation during the study
- Inability to comply with protocol or likely non-cooperation
- Legal or administrative restrictions on freedom
- Participation in another clinical trial within the last 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
Eye Hospital Zora
Sofia, Bulgaria
Actively Recruiting
2
Specialized Ophthalmological Hospital for Active Treatment
Sofia, Bulgaria
Actively Recruiting
3
Medical Center "Vereya"
Stara Zagora, Bulgaria
Actively Recruiting
4
Nemocnice Havlíčkův
Havlíčkův Brod, Czechia
Actively Recruiting
5
OFTEX ocni
Pardubice, Czechia
Actively Recruiting
6
Oční Centrum
Prague, Czechia
Actively Recruiting
7
Oculus Eye Clinic
Bucharest, Romania
Active, Not Recruiting
8
Ofta Total Clinic
Sibiu, Romania
Active, Not Recruiting
9
Medoptic Clinic
Suceava, Romania
Active, Not Recruiting
10
Oftalvist
Alicante, Spain
Actively Recruiting
11
Hospital Universitario Ramón y Cajal
Madrid, Spain
Actively Recruiting
12
OMIQ Hospital Universitari
Sant Cugat del Vallès, Spain
Active, Not Recruiting
13
University Hopital Complex of Santiago de Compostela
Santiago de Compostela, Spain
Active, Not Recruiting
14
Oftalvist
Valencia, Spain
Actively Recruiting
Research Team
C
Carl Zeiss Meditec AG
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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