Actively Recruiting
Extended-field Proton Therapy for Cervical Cancer
Led by National Taiwan University Hospital · Updated on 2025-12-23
44
Participants Needed
2
Research Sites
239 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Severe lymphopenia is a common complication of extended-field radiotherapy in cervical cancer, significantly impacting immune function and clinical outcomes. This study aims to evaluate whether proton therapy, with its superior dose distribution, can reduce lymphopenia and improve survival and toxicity profiles compared to photon therapy.
CONDITIONS
Official Title
Extended-field Proton Therapy for Cervical Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed cervical cancer, stage 63 IIIC
- Age between 20 and 85 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- Eligible for extended-field radiotherapy as determined by the treating physician
- Induction chemotherapy with paclitaxel and carboplatin allowed if duration is 64 6 weeks or 64 2 cycles
- RT alone, or concurrent single-agent chemotherapy with weekly cisplatin or carboplatin during radiation therapy allowed
- Consolidative chemotherapy or immunotherapy after radiation therapy allowed
You will not qualify if you...
- Prior history of pelvic or abdominal radiotherapy
- Presence of distant metastases or other active malignancies within the past 5 years, except non-melanoma skin cancer
- Severe comorbid conditions such as uncontrolled diabetes, cardiovascular disease, or autoimmune disorders
- Pregnancy or breastfeeding at enrollment
- Psychiatric or social conditions limiting compliance with study requirements or follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
National Taiwan University Hospital
Taipei, Taiwan, 100
Actively Recruiting
2
Chang Gung Memorial Hospital
Taoyuan, Taiwan
Actively Recruiting
Research Team
J
Jenny Ling-Yu Chen Attending Physician, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here