Actively Recruiting
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
Led by University of California, San Francisco · Updated on 2025-11-21
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
T
Tobacco Related Disease Research Program
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to study tobacco use and provide tobacco treatment among people experiencing homelessness in California, specifically in San Francisco and Los Angeles. The study focuses on verifying tobacco abstinence through biochemical methods, including expired carbon monoxide (CO) measurements, and evaluates both short-term and longer-term tobacco abstinence outcomes. It also looks at reductions in smoking and the longest duration of abstinence as secondary goals. Participants will be randomly assigned to one of two groups. The intervention group receives six months of pharmacist consultation, monthly nicotine replacement therapy (NRT) which may include patch, gum, or lozenge forms, and wellness coaching delivered by phone weekly to monthly addressing tobacco use and related life challenges. The control group receives pharmacist consultation and monthly NRT for three months only. Follow-up visits occur at one, three, and six months to monitor progress. Throughout the study, participants provide CO samples to biochemically confirm smoking status and complete questionnaires. Researchers measure attendance at coaching sessions, use of NRT, and tobacco abstinence at six months as primary outcomes. Secondary outcomes include abstinence at three months and reductions in CO levels. The total study participation duration includes follow-ups up to six months, with ongoing assessment of tobacco use and wellness support.
CONDITIONS
Brief Title
Extended Intervention for Tobacco Use (EXIT) for People Experiencing Homelessness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to understand and comply with all study procedures
- Willing and able to sign informed consent
- Currently homeless as defined by the Homeless Emergency and Rapid Transition to Housing Act
- Currently smoking at least 5 cigarettes per day, verified by expired carbon monoxide (CO) ≥ 8 ppm
- Intention to quit smoking within the next six months
- English speaking
You will not qualify if you...
- Any contraindication to study procedures or assessments
- Any reason preventing use of nicotine replacement therapy, such as pregnancy or recent myocardial infarction within the past two weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 to 6 months
Participants receive pharmacist consultation and monthly delivery of nicotine replacement therapy (NRT). The experimental group also receives weekly-to-monthly telephone wellness coaching and an additional pharmacist session for up to 6 months.
Monthly visits for NRT delivery; weekly-to-monthly telephone coaching sessions for up to 6 months in the experimental group
Duration - 6 months
Participants provide expired carbon monoxide samples and complete questionnaires to verify tobacco abstinence at 1, 3, and 6 months.
3 visits at 1, 3, and 6 months
Trial Site Locations
Total: 1 location
1
University of California, San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
J
Jessica Alway
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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