Actively Recruiting
Extended Mesenteric Resection in Ileocecal Crohn's Disease.
Led by Odense University Hospital · Updated on 2026-01-15
204
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The EXCEED project aims to study the role of the mesentery in disease recurrence in Crohn's disease (CD), as evidence suggests that including the mesentery when doing ileocecal resections can significantly reduce recurrence rates. The EXCEED study is a blinded randomised clinical trial with 204 participants having ileocecal Crohn's disease requiring resection. Participants will undergo either "standard" mesocolic sparing resection or extended mesocolic resection to assess its impact on reducing recurrence at the anastomotic site. The primary endpoint is endoscopic recurrence 12 months postoperatively. Additionally, the study aims to evaluate the efficacy of different surveillance modalities in detecting anastomotic site recurrence. These examinations will be conducted pre- and postoperatively for a cohort of 20 participants. Through this study, we seek to understand the mesentery's role in Crohn's disease recurrence and identify effective non-invasive methods for postoperative monitoring.
CONDITIONS
Official Title
Extended Mesenteric Resection in Ileocecal Crohn's Disease.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients above the age of 18 scheduled for ileocecal resection due to Crohn's disease.
- Relevant endoscopy and imaging within the last 6 months.
- Diagnosis of "simple" ileocecal Crohn's disease limited to ileocecal disease with a maximum of 40 cm of affected ileum.
You will not qualify if you...
- Previous ileocecal resection.
- Inability to understand Danish or another Nordic language.
- Inability to comprehend the purpose and design of the project.
- Pregnancy or lactation.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Odense University Hospital
Odense, Denmark, 5000
Actively Recruiting
Research Team
J
Jens K Bælum, MD
CONTACT
M
Mark B Ellebæk, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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