Actively Recruiting
Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients
Led by Texas Tech University Health Sciences Center, El Paso · Updated on 2026-05-08
40
Participants Needed
3
Research Sites
91 weeks
Total Duration
On this page
Sponsors
T
Texas Tech University Health Sciences Center, El Paso
Lead Sponsor
U
University of Southern California
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if taking an antibiotic pill for 7 days after surgery reduces the risk of wound infection in adults with poorly controlled diabetes who have surgery to fix a broken bone in the leg, ankle, or foot. It will also learn about the safety of the extended antibiotic course. The main questions it aims to answer are: Does a 7-day antibiotic course after surgery lower the rate of wound infection within 90 days? What medical problems do participants have when taking the extended antibiotic course? Researchers will compare a 7-day course of an oral antibiotic (cefadroxil) to standard care (no additional antibiotics after surgery) to see if the extended course reduces infections. Participants will: Take an antibiotic pill or receive standard care for 7 days after surgery Receive a phone call from the study team about 1 week after surgery Visit the clinic at 3 weeks, 6 weeks, and 3 months after surgery for checkups
CONDITIONS
Official Title
Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Low extremity fracture requiring surgical treatment
- Uncontrolled diabetes (Hemoglobin A1c > 7.0 or random glucose > 200 mg/dL)
- Age 18 years or older
- Able to provide informed consent
- English or Spanish speaker
You will not qualify if you...
- Known allergy to prescribed antibiotic and pre-determined alternatives
- Open fractures
- Current infection requiring antibiotic treatment
- Immunocompromised status (chemotherapy, immunosuppressant medications)
- End-stage renal disease that medication dosing cannot be adjusted for
- Pregnant or breast-feeding
- Unable to comply with follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University of Southern California
Los Angeles, California, United States, 90033
Actively Recruiting
2
University Medical Center of El Paso
El Paso, Texas, United States, 79905
Actively Recruiting
3
Texas Tech Health El Paso
El Paso, Texas, United States, 79912
Actively Recruiting
Research Team
T
Taylor M Yong, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here