Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06675955

An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment

Led by Hoffmann-La Roche · Updated on 2026-02-18

500

Participants Needed

44

Research Sites

263 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The study will evaluate the physical impact of MS from participant's perspective, provide continued access to ocrelizumab and assess the safety and tolerability of ocrelizumab. From Protocol Version 6 onwards, treatment within this study will be limited to the currently approved doses of ocrelizumab, 600 milligrams (mg), intravenous (IV) infusion or 920 mg, subcutaneous (SC) injection.

CONDITIONS

Official Title

An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Participants must have been receiving ongoing ocrelizumab treatment in specified parent studies at the time of roll-over
  • Participants must not have access to ocrelizumab treatment locally
  • First dose in this extension study must be given no earlier than 5 months after last dose in parent study
  • Negative urine pregnancy test within 24 hours before first dose for participants of childbearing potential
Not Eligible

You will not qualify if you...

  • Ocrelizumab treatment is commercially available and accessible in the participant's country
  • Ocrelizumab is available through a Post Trial Access Program and accessible to the participant
  • Permanent premature discontinuation of ocrelizumab during the parent study or before first dose in extension study
  • Any condition that may interfere with safety interpretation or increase treatment risks as judged by investigator
  • Current participation in any other therapeutic clinical trial besides the parent study
  • Immunocompromised state
  • Known active malignancy or under active monitoring for cancer recurrence
  • Presence of other known neurological disorders

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 44 locations

1

CHU Amiens Hopital Sud

Amiens Cedex1, France, 80054

Actively Recruiting

2

CHU de Besancon Hopital Jean Minjoz

Besançon, France, 25030

Actively Recruiting

3

Groupe Hospitalier Pellegrin

Bordeaux, France, 33076

Actively Recruiting

4

CHU Brest Hopital La Cavale Blanche

Brest, France, 29609

Actively Recruiting

5

Hopital neurologique Pierre Wertheimer - CHU Lyon

Bron, France, 69677

Actively Recruiting

6

CHU De Caen

Caen, France, 14033

Actively Recruiting

7

Hopital Gabriel Montpied CHU de Clermont-Ferrand

Clermont-Ferrand, France, 63003

Withdrawn

8

CH St Vincent de Paul

Lille, France, 59000

Actively Recruiting

9

Hopital Gui de Chauliac

Montpellier, France, 34295

Actively Recruiting

10

Hopital Nord Laennec

Nantes, France, 44093

Actively Recruiting

11

Hôpital Pasteur

Nice, France, 06002

Actively Recruiting

12

GroupeHospitalo-Universitaire Caremeau

Nîmes, France, 30029

Actively Recruiting

13

Hopital de Hautepierre

Strasbourg, France, 67098

Actively Recruiting

14

NeuroPoint Gesellschaft fur vorbeugende Gesundheitspflege mbH

Ulm, Germany, 89073

Actively Recruiting

15

Studienzentrum Nordwest Dr med Joachim Springub Herr Wolfgang Schwarz

Westerstede, Germany, 26655

Actively Recruiting

16

Deutsche Klinik für Diagnostik

Wiesbaden, Germany, 65191

Actively Recruiting

17

Krasnoyarsk State Medical Academy

Krasnoyarsk, Krasnoyarsk Krai, Russia, 660022

Actively Recruiting

18

FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency

Krasnoyarsk, Krasnoyarsk Krai, Russia, 660037

Actively Recruiting

19

City Clinical Hospital #24

Moscow, Moscow Oblast, Russia, 127015

Actively Recruiting

20

Federal center of brain research and neurotechnologies

Moskva, Moscow Oblast, Russia, 117997

Actively Recruiting

21

National Center of Social Significant Disease

Saint Petersburg, Sankt-Peterburg, Russia, 197110

Actively Recruiting

22

LLC Osnova

Saint Petersburg, Sankt-Peterburg, Russia, 197341

Actively Recruiting

23

N.P. Bechtereva Institute of the Human Brain

Saint Petersburg, Sankt-Peterburg, Russia, 197376

Actively Recruiting

24

City Hospital #40 of Kurortniy Administrative District

Saint Petersburg, Sankt-Peterburg, Russia, 197706

Actively Recruiting

25

SHI Sverdlovsk Regional Clinical Hospital #1

Yekaterinburg, Sverdlovsk Oblast, Russia, 620102

Actively Recruiting

26

Vertebronevrologiya LLC

Kazan', Tatarstan Republic, Russia, 420043

Actively Recruiting

27

Ulyanovsk Regional Clinical Hospital

Ulyanovsk, Ulyanovsk Oblast, Russia, 432063

Actively Recruiting

28

Center of Cardiology and Neurology

Kirov, Russia, 610007

Actively Recruiting

29

Regional clinical hospital named after prof. S.V. Ochapovsky

Krasnodar, Russia, 350086

Actively Recruiting

30

FSBIH Siberian Regional Medical Centre of FMBA of Russia

Novosibirsk, Russia, 630007

Actively Recruiting

31

Perm SMA n.a. academ. E.A. Vagner

Perm, Russia, 614990

Actively Recruiting

32

5th Cherkasy City Center of Primary Health Care

Cherkasy, Ukraine, 18029

Actively Recruiting

33

Mun.Med.Proph.Inst.?Chernihiv Reg.Hosp.?

Chernihiv, Ukraine, 14029

Actively Recruiting

34

Bukovinsky SMU RMI Chernivtsi RCH

Chernivtsi, Ukraine, 58002

Actively Recruiting

35

SI USSRI of Medical and Social Problems of Disabilities of MOHU

Dnipro, Ukraine, 49027

Actively Recruiting

36

Regional Clinical Hospital

Ivano-Frankivsk, Ukraine, 76008

Actively Recruiting

37

St.In.Inst. of Neurol.Psych.and Narcol.of the AMSU

Kharkiv, Ukraine, 61068

Actively Recruiting

38

Medical Center Dopomoga Plus

Kyiv, Ukraine, 02123

Actively Recruiting

39

Medical Center of Private Execution First Private Clinic

Kyiv, Ukraine, 03037

Actively Recruiting

40

Volyn Regional Clinical Hospital

Lutsk, Ukraine, 43005

Actively Recruiting

41

Lvivska oblasna tsentralna likarnia

Lviv, Ukraine, 79010

Actively Recruiting

42

Medical Clinical Research Center of Medical Center LLC Health Clinic

Vinnytsi, Ukraine, 21009

Actively Recruiting

43

LCC "Medical center "Unimed"

Zaporizhzhia, Ukraine, 69035

Actively Recruiting

44

Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council

Zaporizhzhia, Ukraine, 69600

Actively Recruiting

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Research Team

R

Reference Study ID Number: MN45053 https://forpatients.roche.com/

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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