Actively Recruiting
Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)
Led by Merck Sharp & Dohme LLC · Updated on 2026-04-06
130
Participants Needed
56
Research Sites
206 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for new ways to treat people with a type of pulmonary hypertension called combined postcapillary and precapillary pulmonary hypertension (Cpc-PH). This study focuses on Cpc-PH that is caused by heart failure with preserved ejection fraction (HFpEF). Researchers want to know if the study treatment, sotatercept, can treat people with Cpc-PH caused by HFpEF. This is an extension study, which means people who took part in a certain study on sotatercept for Cpc-PH (called a parent study) may be able to join this study. In this extension study, people will take sotatercept and researchers will follow their health for a longer time. The main goal of this extension study is to learn about the long-term safety of sotatercept and if people tolerate it over a longer period of time.
CONDITIONS
Official Title
Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Completed MK-7962-007 (CADENCE) study (Visit 9 and end of treatment visit) without stopping study intervention
- Able to safely enroll into MK-7962-007 (HARMONIZE) study
You will not qualify if you...
- Diagnosis of pulmonary hypertension in WHO Group 1, 3, 4, or 5
- History of study intervention interruption
- Pregnant or breastfeeding
- Chronic liver disease with severe impairment or cirrhosis
- Anticipated or past more than 1 valve replacement or repair
- Severe tricuspid regurgitation due to primary valvular disease
- Anticipated or past heart transplant or ventricular assist device implantation
- Prior exposure to luspatercept
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 56 locations
1
Pulmonary Associates, PA ( Site 1008)
Phoenix, Arizona, United States, 85032
Active, Not Recruiting
2
Jeffrey S. Sager, MD Medical Corporation ( Site 1060)
Santa Barbara, California, United States, 93105
Active, Not Recruiting
3
Stanford University Medical Center ( Site 1024)
Stanford, California, United States, 94305
Active, Not Recruiting
4
South Denver Cardiology Associates ( Site 1091)
Littleton, Colorado, United States, 80120
Active, Not Recruiting
5
Yale New Haven Hospital ( Site 1093)
New Haven, Connecticut, United States, 06520
Active, Not Recruiting
6
AdventHealth Orlando ( Site 1058)
Orlando, Florida, United States, 32803
Active, Not Recruiting
7
The Emory Clinic ( Site 1030)
Atlanta, Georgia, United States, 30322
Actively Recruiting
8
Norton Pulmonary Specialists ( Site 1066)
Louisville, Kentucky, United States, 40202
Active, Not Recruiting
9
University Of Nebraska Medical Center ( Site 1053)
Omaha, Nebraska, United States, 68198
Active, Not Recruiting
10
Weill Cornell Medical Center ( Site 1046)
New York, New York, United States, 10065
Active, Not Recruiting
11
Duke University Medical Center ( Site 1026)
Durham, North Carolina, United States, 27710-4000
Actively Recruiting
12
The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001)
Cincinnati, Ohio, United States, 45219
Active, Not Recruiting
13
The Cleveland Clinic Foundation. ( Site 1065)
Cleveland, Ohio, United States, 44195
Active, Not Recruiting
14
The Ohio State University Wexner Medical Center ( Site 1032)
Columbus, Ohio, United States, 43210
Active, Not Recruiting
15
Allegheny General Hospital ( Site 1088)
Pittsburgh, Pennsylvania, United States, 15212-4737
Active, Not Recruiting
16
Lankenau Medical Center ( Site 1089)
Wynnewood, Pennsylvania, United States, 19096
Active, Not Recruiting
17
Rhode Island Hospital ( Site 1039)
Providence, Rhode Island, United States, 02903
Active, Not Recruiting
18
Medical University of South Carolina ( Site 1003)
Charleston, South Carolina, United States, 29425
Active, Not Recruiting
19
Statcare Pulmonary Consultants ( Site 1031)
Knoxville, Tennessee, United States, 37919
Active, Not Recruiting
20
Intermountain Medical Center ( Site 1079)
Murray, Utah, United States, 84107
Active, Not Recruiting
21
Inova Fairfax Medical Campus ( Site 1078)
Falls Church, Virginia, United States, 22042
Active, Not Recruiting
22
Pulmonary Associates of Richmond - West Broad Street ( Site 1069)
Richmond, Virginia, United States, 23230
Active, Not Recruiting
23
Université Libre de Bruxelles - Hôpital Erasme ( Site 0100)
Brussels, Bruxelles-Capitale, Region de, Belgium, 1070
Active, Not Recruiting
24
Hamilton Health Sciences Hamilton General Hospital ( Site 0004)
Hamilton, Ontario, Canada, L8L 2X2
Active, Not Recruiting
25
Centre Hospitalier Universitaire de Nice - Hopital Pasteur ( Site 0206)
Nice, Alpes-Maritimes, France, 06000
Active, Not Recruiting
26
Hopital Arnaud de Villeneuve ( Site 0200)
Montpellier, Herault, France, 34295
Active, Not Recruiting
27
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes ( Site 0205)
Saint-Herblain, Loire-Atlantique, France, 44800
Active, Not Recruiting
28
Centre Hopitalier Universitaire d'Angers ( Site 0204)
Angers, Maine-et-Loire, France, 49100
Active, Not Recruiting
29
CHU de Rouen ( Site 0203)
Rouen, Seine-Maritime, France, 76031
Active, Not Recruiting
30
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0202)
Le Kremlin-Bicêtre, Val-de-Marne, France, 94270
Active, Not Recruiting
31
Thoraxklinik-Heidelberg gGmbH ( Site 0309)
Heidelberg, Baden-Wurttemberg, Germany, 69126
Active, Not Recruiting
32
Krankenhaus Neuwittelsbach ( Site 0310)
München, Bavaria, Germany, 80639
Actively Recruiting
33
UKGM Gießen/Marburg ( Site 0312)
Giessen, Hesse, Germany, 35392
Active, Not Recruiting
34
Universitaetsklinikum Koeln ( Site 0311)
Cologne, North Rhine-Westphalia, Germany, 50937
Active, Not Recruiting
35
Universitätsmedizin Johannes Gutenberg Universität Mainz ( Site 0315)
Mainz, Rhineland-Palatinate, Germany, 55131
Active, Not Recruiting
36
Universitaetsklinikum Carl Gustav Carus Dresden ( Site 0301)
Dresden, Saxony, Germany, 01307
Actively Recruiting
37
DRK Kliniken Berlin Westend ( Site 0307)
Berlin, Germany, 14050
Actively Recruiting
38
Rambam Health Care Campus ( Site 0403)
Haifa, Israel, 3109601
Active, Not Recruiting
39
Edith Wolfson Medical Center ( Site 0404)
Holon, Israel, 5810001
Active, Not Recruiting
40
Hadassah Medical Center ( Site 0402)
Jerusalem, Israel, 9112001
Active, Not Recruiting
41
Meir Medical Center ( Site 0401)
Kfar Saba, Israel, 4428164
Active, Not Recruiting
42
ZIV Medical Center ( Site 0400)
Safed, Israel, 1311001
Active, Not Recruiting
43
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 0502)
Bergamo, Lombardy, Italy, 24127
Active, Not Recruiting
44
Fondazione IRCCS Policlinico San Matteo ( Site 0501)
Pavia, Italy, 27100
Active, Not Recruiting
45
AOU Policlinico Umberto I ( Site 0500)
Roma, Italy, 00161
Active, Not Recruiting
46
Unidad de Investigacion Clinica en Medicina, S.C. ( Site 2505)
Monterrey, Nuevo León, Mexico, 64718
Actively Recruiting
47
Krakowski Szpital Specjalistyczny im. Jana Pawła II-Oddzial Kliniczny Chorob Serca i Naczyn z Podod ( Site 0600)
Krakow, Lesser Poland Voivodeship, Poland, 31-202
Active, Not Recruiting
48
Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego ( Site 0601)
Lublin, Lublin Voivodeship, Poland, 20-718
Active, Not Recruiting
49
Uniwersytecki Szpital Kliniczny w Bialymstoku ( Site 0603)
Bialystok, Podlaskie Voivodeship, Poland, 15-276
Active, Not Recruiting
50
Hospital Costa del Sol ( Site 0704)
Marbella, Malaga, Spain, 29603
Active, Not Recruiting
51
Hospital Clinic I Provincial de Barcelona ( Site 0701)
Barcelona, Spain, 08036
Active, Not Recruiting
52
Hospital Universitario 12 de Octubre ( Site 0702)
Madrid, Spain, 28041
Active, Not Recruiting
53
Hospital Universitario Virgen Macarena ( Site 0705)
Seville, Spain, 41009
Active, Not Recruiting
54
HOSPITAL GENERAL UNIVERSITARIO DE TOLEDO ( Site 0703)
Toledo, Spain, 45007
Active, Not Recruiting
55
Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 0800)
Gothenburg, Västra Götaland County, Sweden, 413 46
Active, Not Recruiting
56
Hammersmith Hospital-Department of Cardiology ( Site 0900)
London, London, City of, United Kingdom, W12 OHS
Active, Not Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here