Actively Recruiting
External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients
Led by Infanta Leonor University Hospital · Updated on 2025-12-30
500
Participants Needed
12
Research Sites
160 weeks
Total Duration
On this page
Sponsors
I
Infanta Leonor University Hospital
Lead Sponsor
F
Fundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Leonor
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.
CONDITIONS
Official Title
External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years
- Objectively confirmed acute symptomatic venous thromboembolism (deep vein thrombosis and/or pulmonary embolism)
- Ability to provide written or electronic informed consent
You will not qualify if you...
- Suspicion of cancer during the initial diagnostic evaluation for VTE
- Participation in another interventional study that may interfere with outcomes
- Inability or refusal to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
Hospital Clínic
Barcelona, Barcelona, Spain
Actively Recruiting
2
Hospital Universitario Infanta Leonor
Madrid, Madrid, Spain, 28051
Actively Recruiting
3
Hospital Universitario La Paz
Madrid, Madrid, Spain, 28051
Actively Recruiting
4
Hospital Universitario Príncipe de Asturias
Madrid, Madrid, Spain, 28051
Actively Recruiting
5
Hospital Universitatio del Sureste
Madrid, Madrid, Spain, 28051
Actively Recruiting
6
Hospital Universitario de Móstoles
Madrid, Madrid, Spain
Actively Recruiting
7
Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Murcia, Spain
Actively Recruiting
8
Hospital Universitario Morales Meseguer
Murcia, Murcia, Spain
Actively Recruiting
9
Hospital San Agustín
Avilés, Principality of Asturias, Spain
Actively Recruiting
10
Hospital Universitario Son Llatzer
Balea, Spain
Actively Recruiting
11
Hospital Universitario 12 de Octubre
Madrid, Spain
Actively Recruiting
12
Hospital Universitario de Fuenlabrada
Madrid, Spain
Actively Recruiting
Research Team
A
Anabel Franco Moreno, MD, PhD
CONTACT
A
Anabel Franco Moreno
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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