Actively Recruiting
Extracellular RNA Biomarkers of Myotonic Dystrophy
Led by Massachusetts General Hospital · Updated on 2025-11-24
215
Participants Needed
3
Research Sites
364 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
B
Beth Israel Deaconess Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of muscular dystrophies by examining a urine sample and a blood sample.
CONDITIONS
Official Title
Extracellular RNA Biomarkers of Myotonic Dystrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects with DM1 or DM2 confirmed by genetic testing or clinical criteria
- Able to provide informed consent or assent
- Males and females aged 5 years and older for single biofluid collection
- Males and females aged 14 years and older with DM1 for repeated measurements
- Males and females aged 18 to 65 years for biofluid collection and muscle biopsy
You will not qualify if you...
- History of immunosuppression, coagulopathy, liver or kidney disease, HIV, or hepatitis B or C
- Use of anti-platelet drugs within 7 days before blood draw or biopsy
- Use of anticoagulants within 60 days before blood draw or biopsy
- Active drug or alcohol use or dependence interfering with wound care
- Women who are pregnant, planning pregnancy, or have a positive pregnancy test
- Inability or unwillingness to provide written informed consent or assent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129
Actively Recruiting
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
Actively Recruiting
3
University of Texas Southwestern
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
T
Tamkin Shahraki, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here