Study of Micro RNA in Blood of Newborns With Severe Congenital Heart Disease Undergoing Heart Surgery in Their First Week

What this Trial Is About

Newborns diagnosed with severe congenital heart disease CHD face a higher risk of developing blood clots after cardiac surgery, but the molecular reasons behind this clotting tendency are not well understood. This research aims to study these mechanisms by collecting and analyzing blood samples from neonates with severe CHD during their early life period. The study involves neonates who will undergo corrective heart surgery within the first week of life under cardiopulmonary bypass at Boston Childrens Hospital. Researchers will collect discarded blood samples from routine clinical lab tests taken before and after surgery to study microRNA profiles related to clotting. During the study, plasma samples will be collected at two timepoints before and after surgery. Researchers will examine microRNA in whole blood samples two days after collection to better understand clotting processes in these newborns. The study will follow participants from birth through the early postoperative period, with data collected as part of standard care and additional analysis performed on these samples.

Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis