PREDICT-EV Study on Extracellular Vesicles and Blood Clotting Changes to Predict Stroke Risk in Adults with or without Transient Ischemic Attack

What this Trial Is About

This research aims to identify if a new biomarker related to blood clot risk, called endothelial derived extracellular vesicles, along with changes in blood clotting time, can predict which patients with a Transient Ischemic Attack TIA are most likely to have a stroke. The study focuses on TIA patients, as over 25% of ischemic stroke cases occur in people who previously had a TIA. Stroke is a leading cause of disability, and preventing strokes in high-risk patients is a national health priority. The study will follow 300 participants over 12 months, divided into four groups healthy individuals without stroke or TIA history people referred to TIA clinics but found not to have TIA patients confirmed with TIA who did not have a stroke within 12 months and patients with TIA who did have a stroke within 12 months. Researchers will monitor and compare changes in extracellular vesicle levels and prothrombin time in these groups to assess stroke risk. Participants will undergo blood tests to measure the biomarker and clotting time, with follow-up over three years to observe changes. The study collects clinical information and imaging results to confirm stroke or TIA diagnosis. Researchers will also track patient diet status and medication use. The main outcomes are changes in the extracellular vesicles and prothrombin time, which may help identify those at highest risk for stroke after TIA.

Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke