Actively Recruiting
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
Led by Careggi Hospital · Updated on 2025-02-12
1000
Participants Needed
1
Research Sites
256 weeks
Total Duration
On this page
Sponsors
C
Careggi Hospital
Lead Sponsor
U
University of Florence
Collaborating Sponsor
AI-Summary
What this Trial Is About
Worldwide, the use of Extracorporeal Blood Purification (EBP) in everyday clinical practice is becoming increasingly common, particularly in critical care settings. The efficacy of most of these treatments on removal of inflammatory mediators is the main rationale behind the use of EBP in critically ill patients with multiorgan dysfunction. Nonetheless, there are still some doubts as to the clinical efficacy of bacterial toxins and cytokines removal and many clinical trials aiming at exploring the effect of EBP on long-term outcomes of septic patients have failed to demonstrate consistent results regarding 28 day- or hospital-mortality rates. The primary aim of this observational prospective web-based registry is to define the possible clusters of critically ill patients - treated with extracorporeal blood purification therapies worldwide - who are homogeneous regarding both clinical and treatment characteristics and seem to benefit the most from EBP.
CONDITIONS
Official Title
Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Admission to ICU
- Indications for at least one extracorporeal blood purification treatment: Continuous Renal Replacement Therapy, Intermittent Hemodialysis, Hybrid therapies for renal support or replacement
- Indications for immunomodulation therapy using hemodiafilters or cartridges aimed at removing cytokines and/or endotoxins
- Treatments initiated based on physician judgment reflecting current clinical practice
You will not qualify if you...
- Contraindications to the use of the extracorporeal blood purification therapy as per device instructions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Azienda Ospedaliero Universitaria Careggi
Florence, Italy, 50100
Actively Recruiting
Research Team
G
Gianluca Villa, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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