Actively Recruiting
Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study
Led by Universidade Federal do Rio de Janeiro · Updated on 2024-07-23
1
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The presence of high levels of respiratory effort in patients under mechanical ventilation may worsen the adjacent lung injury even after adapting protective ventilation. Primary outcome: To evaluate the failure rate of weaning from IMV and its relationship with the lower and upper extremes of respiratory effort and the upper extreme of dynamic pulmonary stress during the first 7 days of spontaneous ventilation. Analyze the influence of these extremes based on the thresholds of Pocc, P0.1 and their derivatives Pmus, Ptp, din and MP: in relation to days off MV (in the 28-day interval); Total weaning time; Rate and time for tracheostomy; Length of stay in the ICU and hospital; In-hospital mortality rate. CAAE: 78185823.4.0000.5249. Prospective multicenter observational study, carried out in the ICUs of Glória D'or and Niteroi D'or hospitals, from January 2024 to July 2026, in patients over 18 years old, undergoing orotracheal intubation and IMV, in their first 7 days on spontaneous ventilation. Hypothesis: Extremes of respiratory effort and dynamic pulmonary stress would be associated with a higher rate of weaning from IMV, as well as longer time on IMV and subsequent longer hospital stay.
CONDITIONS
Official Title
Extremes of Respiratory Effort in Weaning Failure From Mechanical Ventilation: a Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Admitted to Glória D'or hospital
- Undergoing orotracheal intubation and invasive mechanical ventilation
- In their first 7 days of spontaneous ventilation
- Agree to participate by signing informed consent or via legal representative
You will not qualify if you...
- Neuromuscular disease
- Phrenic nerve injury
- Mechanical ventilation for less than 24 hours
- Previously tracheostomized patient
- Age under 18
- Use of neuromuscular blockers for more than 72 hours
- COPD
- Pulmonary fibrosis
- Pregnancy
- Patient under palliative care
- COVID-19 pneumonia
- Patients reintubated after extubation in this hospitalization for less than 3 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Gloria D'or hospital
Rio de Janeiro, Brazil, 22211230
Actively Recruiting
Research Team
A
Amanda Pereira da cruz
CONTACT
P
Pedro Leme Silva
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here