EXtubation Related Complications - an International Observational Study To Understand the Impact and BEst Practices in the Operating Room and Intensive Care Unit - the EXTUBE Study

What this Trial Is About

Researchers are studying extubation-related complications in adults who undergo extubation of an endotracheal tube after general anesthesia or critical illness. This international, multicenter observational study aims to estimate how often immediate complications occur, identify risk factors, assess outcomes up to hospital discharge, and evaluate adherence to clinical guidelines. Extubation can be risky, with serious events like cardiac arrest or brain damage possible, yet there is limited large-scale data on complication rates and practices. The study observes patients undergoing extubation in various settings including operating rooms, out-of-OR anesthesia locations, and intensive care units. It tracks complications and clinical practices without altering standard care. The research collects data on immediate events within 60 minutes after extubation, as well as outcomes like re-intubation and mortality within days. There are no experimental treatments; instead, the study focuses on monitoring and recording extubation-related events. Participants will have their extubation monitored for complications such as severe hypoxemia, cardiac arrest, airway issues, and more within one hour of extubation. Additional outcomes, including mortality up to seven days and re-intubation within 48 hours, will be recorded. The study also collects information on airway management difficulties and use of respiratory support. Data on adherence to extubation guidelines and patient outcomes will be analyzed. Participation duration varies, with enrollment during the specified study window and follow-up until hospital discharge or the defined outcome periods.

EXtubation Related Complications - the EXTUBE Study (EXTUBE)