Effects of Low-Dose Atropine Eye Drops on Eye Alignment and Binocular Vision in Children with Exotropia and Myopia

What this Trial Is About

Researchers are investigating the effects of low concentration atropine eye drops on ocular alignment and binocular vision in children with exotropia, exophoria, and myopia. Atropine is known to reduce the power of accommodation by paralyzing the ciliary muscle and dilating the pupil, which can impact binocular vision and eye alignment. This trial aims to better understand how atropine influences these factors, especially since myopia and intermittent exotropia often occur together in children, and atropine is widely used to slow myopia progression. Participants will be randomly assigned to one of three groups 0.05% atropine eye drops, 0.01% atropine eye drops, or placebo eye drops containing 0.1% sodium hyaluronate. Each participant will apply the assigned eye drops to both eyes once every night. The eye drops are prepackaged identically and stored under controlled conditions. This treatment period is planned for up to 2 years, with regular follow-ups to monitor effects. During the study, children will undergo various eye examinations to measure refraction, axial length, stereopsis, fusion, accommodative function, ocular alignment, and other binocular vision parameters at 1 year and 2 years. Researchers will track changes in accommodation amplitude, pupil size, and visual acuity, as well as safety and tolerability. The total participation will last up to 2 years, including regular clinic visits for assessments and monitoring.

A-eyedrops on Ocular Alignment and Binocular Vision