Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID07297849

The Effect of Eyelid Closure on the Quality Index of Keratometric Measurements: a Non-controlled Interventional Study

Led by Vienna Institute for Research in Ocular Surgery · Updated on 2025-12-22

29

Participants Needed

1

Research Sites

N/A

Total Duration

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AI-Summary

What this Trial Is About

Cataract surgery is one of the most commonly performed surgeries worldwide, with increasing focus on achieving precise refractive outcomes and reducing dependence on glasses after surgery. Accurate measurements of the cornea's curvature, known as keratometry, are crucial for selecting the right intraocular lens (IOL) power. However, errors in keratometry can lead to differences between predicted and actual vision after surgery. Dry eye disease, indicated by tear film osmolarity, can affect the accuracy of these measurements. This study investigates whether closing the eyelids for a few minutes can improve keratometry measurement quality in patients flagged for keratometry quality warnings. Participants will undergo a single study visit where four keratometry measurements will be taken on one eye using an ocular biometer called IOLMaster 700. Two measurements will be taken with eyes open and normal blinking, followed by periods of eyelid closure for three minutes before the third and fourth measurements. This simple behavioral intervention is being examined to see if it improves the quality index of keratometric measurements compared to measurements done with eyes open. During the visit, the study eye will be measured twice with eyes open, then the participant will close their eyelids for three minutes before a third measurement, followed by another three-minute eyelid closure before a fourth measurement. Researchers will compare the difference in keratometry quality warnings between the initial and third measurements taken approximately six minutes apart. This approach aims to determine if eyelid closure can reduce measurement variability and improve preoperative biometry accuracy in patients with dry eye or ocular surface disease. Participation involves only a single study day with repeated measurements and no long-term follow-up.

CONDITIONS

Brief Title

Eyelid Closure in Keratometry

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 or older
  • Written informed consent
  • Keratometry quality index "warning"
Not Eligible

You will not qualify if you...

  • Severe corneal conditions that may compromise corneal integrity (such as corneal scarring, etc.)
  • Pregnancy (pregnancy test will be taken in women of reproductive age), nursing women
  • Ocular surgery in the study eye in the three months preceding the study
  • Inability of visual fixation (e.g. in patients with nystagmus)
  • Inability of eyelid closure (e.g. in patients with facial nerve paralysis)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - 1 day

Participants undergo a series of keratometric measurements with eyelid closure to assess the effect on measurement quality.

1 visit (in-person)

Trial Site Locations

Total: 1 location

1

Vienna Institute for Research in Ocular Surgery (VIROS), Department of Ophthalmology

Vienna, State of Vienna, Austria, 1140

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Research Team

A

Andreas Schlatter, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SEQUENTIAL

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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