Actively Recruiting
F18-MHF: Orthopedic Implants-Associated Infection Detection
Led by Emory University · Updated on 2025-07-25
30
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Following intravenous injection of \[F-18\]MHF as a bolus, dynamic PET imaging of the lower limbs will be acquired for approximately 90 minutes. The acquired images will be processed and viewed on a MIMVista or similar workstation. The uptake pattern of \[F-18\]MHF around infected orthopedic knee implant will be determined and compared with its uptake pattern around non-infected knee implants. This study will look at how \[18F\]MHF goes into normal knee replacements and those with suspected infection.
CONDITIONS
Official Title
F18-MHF: Orthopedic Implants-Associated Infection Detection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older who can provide written informed consent and lie still for PET scanning
- Suspected knee prosthetic infection at least 2 months after original implant placement and scheduled for surgical debridement or removal
- Elevated CRP and ESR levels
- Patients 18 years or older who can provide written informed consent and lie still for PET scanning
- Knee prosthesis in place without complications for 6 months or longer
You will not qualify if you...
- Current or recent antimicrobial therapy within 1 month
- Significant comorbidities such as renal failure, septic shock, uncontrolled diabetes
- Other clinically likely infection sites
- Clinical or laboratory suspicion of knee prosthesis infection in asymptomatic cohort
- Recent or current treatment for infected knee prosthesis within 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
Research Team
D
David M Schuster, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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