Actively Recruiting
A Facial Expression-based Personalization Engine for Monitoring and Modulating Engagement in Cognitive Training in Older Adults at Risk for Alzheimer's Disease or Related Dementias
Led by Stanford University · Updated on 2026-04-24
80
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how to improve adherence to computerized cognitive training done at home by older adults at risk for Alzheimer's disease or related dementias. This study tests a facial expression-based personalization engine (FPE) designed to monitor and adjust training in real time, aiming to keep participants effectively engaged and enhance long-term adherence. The study compares cognitive training programs with and without this FPE in older adults at risk for cognitive decline. Participants will engage in a six-week unsupervised cognitive training program called speed of processing training. One group will use the FPE system that tracks facial expressions to assess engagement and modulates task novelty accordingly, while the other group will use traditional computerized cognitive training without this personalized feedback. The study evaluates how this approach influences engagement and adherence. Throughout the intervention, researchers will measure a multi-modal effective engagement index continuously over up to eight weeks. Other assessments include time spent training, self-reported fatigue, memory, and executive function at baseline, post-intervention, and at follow-up six weeks later. The study is randomized and double-blind, with participation possible for adults aged 60 to 89, and includes monitoring to understand how engagement impacts cognitive outcomes.
CONDITIONS
Brief Title
FACE Phase II (a Stage II Trial)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- English speaking
- Aged 60 to 89 years
- Living in a home, or independent- or assisted-living facility
- Adequate visual and hearing acuity
- Stable use of antidepressants, antipsychotics, or anxiolytics for at least 7 days
- Stable use of memory medications for at least 3 months
- No neurological or vascular disorders except minor symptoms approved case-by-case
You will not qualify if you...
- Currently enrolled in another intervention study aimed at improving cognition
- Living in a nursing home
- Diagnosed with Multiple Sclerosis, traumatic brain injury, chronic heart failure, Parkinson's disease, or dementia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 weeks
Participants undergo a 6-week cognitive training intervention using either a personalized facial expression-based interface or traditional computerized training.
Multiple sessions throughout the 6 weeks
Duration - 6 weeks after intervention
Participants complete post-intervention and follow-up assessments of memory and executive function.
2 visits (post-intervention at week 7 and follow-up at week 13)
Trial Site Locations
Total: 1 location
1
Stanford University CogT Lab
Palo Alto, California, United States, 94304-0000
Actively Recruiting
Research Team
F
Feng Vankee Lin, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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